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. 1987 May;84(10):3531–3535. doi: 10.1073/pnas.84.10.3531

Initial localization of the acoustic conditioned stimulus projection system to the cerebellum essential for classical eyelid conditioning.

J E Steinmetz, C G Logan, D J Rosen, J K Thompson, D G Lavond, R F Thompson
PMCID: PMC304905  PMID: 3554242

Abstract

Previous experiments have demonstrated a sufficient and necessary involvement of mossy fibers in projecting conditioned stimulus information to the cerebellum during classical eyelid conditioning in rabbits. Presented here are electrophysiological, anatomical, and lesion data that suggest that cells within the lateral pontine nuclear region may be essentially involved in projecting information concerning the occurrence of acoustic conditioned stimuli to the cerebellum during classical conditioning.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aitkin L. M., Boyd J. Acoustic input to the lateral pontine nuclei. Hear Res. 1978 Oct;1(1):67–77. doi: 10.1016/0378-5955(78)90010-2. [DOI] [PubMed] [Google Scholar]
  2. Clark G. A., McCormick D. A., Lavond D. G., Thompson R. F. Effects of lesions of cerebellar nuclei on conditioned behavioral and hippocampal neuronal responses. Brain Res. 1984 Jan 16;291(1):125–136. doi: 10.1016/0006-8993(84)90658-9. [DOI] [PubMed] [Google Scholar]
  3. Eccles J. C. An instruction-selection theory of learning in the cerebellar cortex. Brain Res. 1977 May 27;127(2):327–352. doi: 10.1016/0006-8993(77)90550-9. [DOI] [PubMed] [Google Scholar]
  4. Huang C. M., Liu G., Huang R. Projections from the cochlear nucleus to the cerebellum. Brain Res. 1982 Jul 22;244(1):1–8. doi: 10.1016/0006-8993(82)90897-6. [DOI] [PubMed] [Google Scholar]
  5. Kawamura K., Brodal A. The tectopontine projection in the cat: an experimental anatomical study with comments on pathweays for teleceptive impulses to the cerebellum. J Comp Neurol. 1973 Jun 1;149(3):371–390. doi: 10.1002/cne.901490306. [DOI] [PubMed] [Google Scholar]
  6. Kawamura K. The pontine projection from the inferior colliculus in the cat. An experimental anatomical study. Brain Res. 1975 Sep 23;95(2-3):309–322. doi: 10.1016/0006-8993(75)90109-2. [DOI] [PubMed] [Google Scholar]
  7. Lavond D. G., Hembree T. L., Thompson R. F. Effect of kainic acid lesions of the cerebellar interpositus nucleus on eyelid conditioning in the rabbit. Brain Res. 1985 Feb 4;326(1):179–182. doi: 10.1016/0006-8993(85)91400-3. [DOI] [PubMed] [Google Scholar]
  8. Lewis J. L., Lo Turco J. J., Solomon P. R. Lesions of the middle cerebellar peduncle disrupt acquisition and retention of the rabbit's classically conditioned nictitating membrane response. Behav Neurosci. 1987 Apr;101(2):151–157. doi: 10.1037//0735-7044.101.2.151. [DOI] [PubMed] [Google Scholar]
  9. Marr D. A theory of cerebellar cortex. J Physiol. 1969 Jun;202(2):437–470. doi: 10.1113/jphysiol.1969.sp008820. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Mauk M. D., Steinmetz J. E., Thompson R. F. Classical conditioning using stimulation of the inferior olive as the unconditioned stimulus. Proc Natl Acad Sci U S A. 1986 Jul;83(14):5349–5353. doi: 10.1073/pnas.83.14.5349. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. McCormick D. A., Clark G. A., Lavond D. G., Thompson R. F. Initial localization of the memory trace for a basic form of learning. Proc Natl Acad Sci U S A. 1982 Apr;79(8):2731–2735. doi: 10.1073/pnas.79.8.2731. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. McCormick D. A., Steinmetz J. E., Thompson R. F. Lesions of the inferior olivary complex cause extinction of the classically conditioned eyeblink response. Brain Res. 1985 Dec 16;359(1-2):120–130. doi: 10.1016/0006-8993(85)91419-2. [DOI] [PubMed] [Google Scholar]
  13. McCormick D. A., Thompson R. F. Cerebellum: essential involvement in the classically conditioned eyelid response. Science. 1984 Jan 20;223(4633):296–299. doi: 10.1126/science.6701513. [DOI] [PubMed] [Google Scholar]
  14. McCormick D. A., Thompson R. F. Neuronal responses of the rabbit cerebellum during acquisition and performance of a classically conditioned nictitating membrane-eyelid response. J Neurosci. 1984 Nov;4(11):2811–2822. doi: 10.1523/JNEUROSCI.04-11-02811.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Mower G., Gibson A., Glickstein M. Tectopontine pathway in the cat: laminar distribution of cells of origin and visual properties of target cells in dorsolateral pontine nucleus. J Neurophysiol. 1979 Jan;42(1 Pt 1):1–15. doi: 10.1152/jn.1979.42.1.1. [DOI] [PubMed] [Google Scholar]
  16. Steinmetz J. E., Rosen D. J., Woodruff-Pak D. S., Lavond D. G., Thompson R. F. Rapid transfer of training occurs when direct mossy fiber stimulation is used as a conditioned stimulus for classical eyelid conditioning. Neurosci Res. 1986 Sep;3(6):606–616. doi: 10.1016/0168-0102(86)90057-x. [DOI] [PubMed] [Google Scholar]
  17. Thompson R. F. The neurobiology of learning and memory. Science. 1986 Aug 29;233(4767):941–947. doi: 10.1126/science.3738519. [DOI] [PubMed] [Google Scholar]

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