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. Author manuscript; available in PMC: 2011 Nov 4.
Published in final edited form as: Neuron. 2010 Nov 4;68(3):428–441. doi: 10.1016/j.neuron.2010.10.020

Figure 4.

Figure 4

EC-APP mice have abnormalities in synaptic activity-related proteins in the DG. Brain sections from mice of the four genotypes were immunostained for calbindin, Fos, or NPY. Immunoreactivity for calbindin in the molecular layer and for NPY in the mossy fiber (MF) pathway was determined by densitometry; Fos-positive neurons were counted in the granular cell layer. Representative coronal sections of the DG from 6-month-old NTG and EC-APP (tTA/tet) mice (A,C,E) and quantitative results from 6- and 13-month-old mice (B,D,F). ANOVA revealed a significant effect of genotype on all measures. *p<0.05 vs. all other groups, or as indicated by brackets with Newman-Keuls post-hoc test. n=14–15 mice/group (6 months) or n=6–9 mice/group (13 months). Values are mean ± SEM.