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Thermodynamic stability of α2D and Glu7 variants. The measured ΔΔGobs is plotted against ΔΔGpred, the contribution to stability differences based on both aromaticity and helical propensity for α2D and Glu7 variants. The data are fit to the linear equation ΔΔGobs =a*ΔΔGα + b*narom + c. The rms deviation of the individual data points from the line is 0.4 kcal mol−1.
