Abstract
The purpose of this investigation is to examine factors involved in the postoperative care of traumatic lacerations. An evidence-based comprehensive literature review was conducted. There are a limited number of scientifically proven studies that guide surgeons and emergency room physicians on postoperative care. Randomized controlled trials must be conducted to further standardize the postoperative protocol for simple facial lacerations.
Keywords: Laceration, wound closure, postoperative care
The management of facial lacerations is common for surgeons who take trauma call at their local hospitals and for emergency room physicians. In fact, we have more calls to the emergency rooms for treatment of soft tissue injuries at our hospitals than we do for bony injuries. Because of the visibility of the face, it should not be surprising that much attention has been given to the technique(s) for the closure of traumatic facial lacerations. Studies are plentiful that evaluate a host of factors, such as methods of cleansing and debridement, types of sutures, layered versus nonlayered closure, use of adhesives rather than sutures, and so on. There is a paucity of information, however, about what to do after the laceration has been closed. Most texts on the management of facial injuries mention very little regarding this topic.
Most of the aftercare recommended for facial lacerations seems to be based upon the varied opinions of the individual surgeon rather than on scientific factors. In fact, there seems to be no consensus, and often what is recommended by one surgeon is castigated by another.
The purpose of this article is to examine the factors involved in postoperative care of traumatic lacerations. We have tried to identify the most scientific information available to make treatment recommendations, but it should be realized that good evidence for much of what is currently being done is not based on science, and just as importantly, there is not much science on this topic to guide the clinician. Although we are discussing the treatment of traumatic facial lacerations, much of the studies that are available have been performed on lacerations elsewhere in the body. However, there is no reason to believe that they aren't applicable the facial region. The information presented here should also apply to incisions made on the face for any reason.
SURGICAL TAPE
Surgical tape to reinforce sutured lacerations at the time of closure and after suture removal is often used as adjunctive wound care. Surgical tape theoretically minimizes skin tension. In a cadaveric study, the reinforcement of surgical tape with mastisol over a sutured skin incision exhibited a slightly higher strength against separating forces when compared with sutures alone, but differences were not statistically significant (15.39 kg versus 14.17 kg).1 Surgical tape also serves as a partially occlusive and microporous dressing, without increasing the risk of infection.2,3
Technique of Application
There are techniques to optimize the efficacy of surgical tapes. Skin preparation with mastisol provides markedly increased adhesive strength in comparison to tincture of benzoin and surgical tapes used without skin preparation.4,5 Steri-strips (3M, Minneapolis, MN) with mastisol adhesive have the longest duration of effective adhesion among the various surgical tapes.2 Steri-strips should ideally be applied in a parallel, nonoverlapping fashion over the mastisol-covered skin.6
Conclusion
To our knowledge, there are no studies evaluating tensile strength, cosmesis, and infection rates when Steri-strips are used as an adjuvant at the time of closure of lacerations and after suture removal. There is reason to believe that continued use of Steri-strips may provide some benefit up to 6 weeks.7 In healing rat wounds, gains in wound strength from collagen formation are exponential up to 42 to 60 days, after which strength plateaus.8 Due to the lack of documented, deleterious effects on wound healing and its speculated provision of tensile support, the application of Steri-strips seems prudent immediately after closure and also after suture removal for a period of time. The longer they can be used, the better the potential effect, at least until 6 weeks postoperatively. However, the duration of use will be based on convenience and compliance for lacerations on the face.
TOPICAL OINTMENTS
There are two main categories of ointments that have been applied to the sutured laceration: petrolatum alone or antibiotic-impregnated petrolatum. Any topical ointment provides a moist environment, whereas an antibiotic-impregnated ointment offers the additional potential benefit of antimicrobial activity. By far, the most commonly used ointment is the latter. The use of topical antibiotics is usually recommended for traumatic lacerations and surgical wounds.9 Although the use of topical antibiotics in simple lacerations has been widely accepted by clinicians,10 the effectiveness of topical antibiotics is still debated and therefore discussion is worthy.
Microbiology
Topical antibiotics aim to decrease infections from common skin pathogens. The most common pathogens for skin and soft tissue infections are Staphylococcus and Streptococcus species. In addition, Corynebacterium, Pasteurella, and Pseudomonas species and Enterobacteriaceae are frequent colonizers of skin infections. When infection occurs from soft tissue trauma, a mixed infection involving anaerobes is common.11,12 Selection of a topical antibiotic should be directed toward these common pathogens (Table 1).
Table 1.
Topical Antimicrobial | Target Bacteria | Limitations |
---|---|---|
Mupirocin | Staphylococcus species (including methicillin-resistant Staphylococcus aureus) | Enterobacteriaceae species |
Streptococcus species | ||
Pasteurella species | ||
Neomycin | Gram negative aerobes | Streptococcus species Anaerobes |
Staphylococcus species | ||
Polymyxin | Pseudomonas aeruginosa | Gram-positive organisms |
Proteus mirabilis | ||
Serratia marcescens | ||
Escherichia coli | ||
Enterobacter | ||
Klebsiella | ||
Bacitracin | Stapholycoccus species | Gram-negative organisms |
Streptococcus species | ||
Clostridia | ||
Corynebacteria | ||
Silver Sulfadiazine | Gram-positive and gram-negative |
The process of re-epithelialization begins within the first 24 hours13 and is completed in approximately 1 week for primarily closed wounds.14 Wounds are most susceptible to infection within the first 2 days.15 Schauerhamer et al inoculated wounds created on guinea pigs with Staphylococcus aureus and Escherichia coli at various time intervals.15 Infections developed in wounds inoculated within the first 48 hours. After this 48-hour cutoff, no wounds became infected.
Maintenance of a Moist Environment
Topical ointments also maintain a moist healing environment, thereby minimizing scab formation. Winter's landmark article on porcine wounds established that the formation of a dry scab on the superficial surface of a wound impairs epithelization.16 Furthermore, he determined that the maintenance of a moist environment without scab formation enhances wound healing. A year later in 1963, Hinman and Maibach confirmed this finding with cultured human cells.17 Several contemporary studies have supported the benefit of a moist environment for optimal wound healing.18,19,20 Last, topical ointments impair dressing adherence, preventing tissue damage upon removal of a dressing.
Effectiveness
Topical antibiotics, in comparison to plain petrolatum, decrease the incidence of infection in simple lacerations. In a prospective, double-blind, controlled trial, the efficacies of (1) bacitracin zinc ointment; (2) neomycin sulfate, bacitracin zinc, and polymyxin B sulfate combination ointment; and (3) silver sulfadiazine cream were compared against a control of petrolatum for 426 uncomplicated repaired lacerations at a military community hospital.21 Patients were instructed to change dressings three times a day and apply topical ointment with both verbal and written instructions. Wound infection rates were 5.5% (6/109) for bacitracin zinc ointment; 4.5% (5/110) for neomycin sulfate, bacitracin zinc, and polymyxin B sulfate combination ointment; 12.1% (12/99) for silver sulfadiazine cream; and 17.6% (19/108) for petrolatum. When the petrolatum control was compared with all three antibiotics, the difference in infection rates were significant (p = 0.0018). When the antibiotics were compared with each other for infection rates, there were no statistically significant differences (p = 0.14). The fact that topical antibiotics have been proven to be effective in decreasing wound infections in comparison to petrolatum is further supported by their ability to decrease bacterial counts in open wounds.22,23 The Dire et al. study (1995) did not compare the incidence of infection when lacerations were left dry or without dressings.21 Another important aspect of the study is that no data were presented on the comparison of topical antibiotics to petrolatum specifically to the head and neck region, even though 54% (232/426) of lacerations involved the head and neck region in this study. As expected, the head and neck region had the lowest infection rate among anatomic locations at 6.0% (14/232).21 It is therefore difficult to elucidate the antibacterial utility of topical antibiotics for head and neck lacerations because the infection rate is already low in this region.
The use of topical antibiotics in sterile dermatologic surgery has not been shown to decrease the incidence of infection in postoperative wounds. In a prospective, double-blind, controlled trial of 884 patients with 1207 sterile wounds from dermatologic surgery at a military institution, no statistically significant differences in infection rates between bacitracin zinc ointment to petrolatum were found (p = 0.37).24 The overall incidence of infection was 3.8% (34/884) with a 4.5% (20/440) infection rate with petrolatum and 3.2% (14/444) infection rate with bacitracin. Again, in this study over 54% (659/1207) of wounds were in the head and neck region, but there was no analysis of infection rates specific to head and neck wounds after dermatologic surgery.24
The literature thus far provides evidence that there is a decreased incidence of infection with the application of topical antibiotics in lacerations, but not for sterile surgical wounds. However, evidence-based literature specific to the usage of topical antibiotics for lacerations and sterile surgical wounds in the head and neck region have not been thoroughly investigated.
Safety, Allergenic Potential, and Resistance
Topical antibiotics are safe to use on human skin and achieve high local concentrations with limited systemic toxicity. Multiple studies have failed to demonstrate any topical antibiotic-mediated toxicity on human keratinocytes and fibroblasts.25,26,27 Though locally nontoxic, allergic potential exists.
Reports of contact dermatitis with the use of various topical antibiotics have been increasing over time. Historically, neomycin has been the most frequent culprit. In 1979, the incidence of neomycin contact dermatitis was reported to be 1% or less in the general population.28 In 1992, a prospective follow-up study of 215 patients having undergone cutaneous surgery found the incidence of contact dermatitis was 5.3% for neomycin.29 More recently, the North American Contact Dermatitis Group found the frequency of contact dermatitis with neomycin to be 10% in a population of 4454 patients referred for diagnostic patch testing.30
At one time, bacitracin was thought to have a low occurrence of contact dermatitis. A randomized controlled study of 922 patients in 1996 found 0.9% of the 444 patients in the bacitracin group to exhibit acute contact dermatitis.24 In contrast, according to the North American Contact Dermatology group, in 2003 the incidence of bacitracin contact dermatitis increased from 1.5% in 1989t o 1990 to 9.2% in 1998 to 2000 when patch tested.31
Several authors agree that the incidence of contact dermatitis to polymyxin B is rare.32,33
To provide the most ideal environment for successful postoperative wound care, the potential for allergic contact dermatitis (manifested as localized, cutaneous erythema and pruritus) and its effects on wound healing should be taken into account, especially in light of recent data supporting a rising incidence of contact dermatitis associated with the application of topical antibiotics. Though positive patch tests show an upward trend of allergic contact dermatitis, a positive patch test does not always correlate with clinical manifestations of allergic contact dermatitis in wounds.24
Antibacterial resistance to topical antibiotics has been reported and is a concern.25 The potential for plasmid-mediated resistance to neomycin has been reported for both gram-positive and gram-negative organisms. Bacitracin-resistant strains to staphylococci have also been established.34
Conclusion
From this review, it seems that postoperative application of topical antibiotics deserves a role in infection prevention and wound healing during the first 48 hours of re-epithelialization.13,15,35 Beyond this initial period, further use may be unwarranted and may lead to increasing resistance, allergy, and sensitivity. It has been proposed to use petrolatum after this initial period to maintain a moist wound and prevent scab formation.35 Further evidence-based studies on the role of topical antibiotics in head and neck lacerations will be needed to confirm this conclusion.
DRESSINGS
There are many functions and potential benefits of dressings placed over facial lacerations (Table 2). However, a strict evidence-based guideline does not exist in the selection of a dressing. The decision should be based upon wound complexity, amount of exudate produced, and risk of infection.7 Although a multitude of tailored dressings exist for specific wounds, our discussion will be limited to dressings used in the management of simple facial lacerations.
Table 2.
•Protect the wound from bacteria and foreign material |
•Absorb exudate from the wound |
•Prevent heat and fluid loss from the wound |
•Provide compression to minimize edema and obliterate dead space |
•Be nonadherent and removable without causing trauma |
•Create a warm, moist occluded environment |
•Cover an unsightly wound |
•Minimize pain |
•Splint or immobilizing the wound |
Cotton Gauze
An argument is frequently made that gauze is more cost-effective and if kept moist with saline provides equal benefit as occlusive dressings. A survey of emergency room physicians shows that most clinicians still use gauze, taped over the topical ointment–covered wound.10 However, the use of gauze makes wounds vulnerable to bacterial contamination from its meshlike nature,36,37 disrupts the healing wound by becoming adherent,38 sheds fibers into the wound,39,40 and requires more frequent dressing changes.41
Fabric Dressings
Telfa (Kendall, Mansfield, MA) is a synthetic nonadherent dressing composed of a core of mildly absorbent cellulose sponge sandwiched between perforated polyester films. In combination with topical antibiotic ointment, Telfa helps to maintain a moist wound environment. Telfa can be used alone or as an interface material in combination with other dressings.7 The main advantages of Telfa are its wide availability, low cost, nonadherence, mildly absorbent qualities, and the ease of custom fitting the material to the wound.7,38 Disadvantages include the tendency to become adherent in highly exudative wounds7 and the requirement for a secondary supportive dressing to maintain its position over the wound.38
The Case for Occlusive Dressings
Winter's discovery that moisture enhances wound healing prompted a paradigm shift toward the use of occlusive dressings.16 Formerly (and often currently), dry gauze is applied, or the wound is allowed to heal exposed to air and protected only by the scab. The term occlusion implies creating a covered, moist wound environment, with the goal of accelerating wound healing. Authors typically do not classify topical ointments as an occlusive dressing.36,38 However, being oil based, one would think that topical ointments provide some degree of occlusion.
Occlusive dressings are either fully occlusive (impermeable to fluid and gas) or partially occlusive (semipermeable to gases like oxygen and water vapor yet still retain fluid impermeability).42 Occlusive dressings speed keratinocyte migration16,43; stimulate keratinocyte, fibroblast, and endothelial cell proliferation by retaining wound fluid44,45; sustain a level of hypoxia to induce angiogenesis and collagen synthesis46,47,48; lower the rate of infection36; and possibly improve cosmetic outcomes.49
Film Dressings
Polyurethane films (e.g., Tegaderm, 3M, Minneapolis, MN) are partially occlusive dressings, allowing gaseous exchange but not fluids. An advantage is that the transparency of film allows easy visualization of the wound. There are three main disadvantages of films. Films cannot absorb fluids and thus fluids can build up under the film, which can break the peripheral seal. They can be difficult to handle because of their inherent stickiness, and this stickiness may also damage new epithelium during removal of the film if applied directly to the wound margins.7,50
Facial Dressing Options
Numerous combinations of dressings for simple sutured facial lacerations exist: topical ointment only, topical ointment and gauze supported by tape, topical ointment and Telfa, an occlusive dressing, and a four-layer technique with Steri-strips, topical ointment, interface dressing (Telfa), all covered by film (Tegaderm) or tape.7,50 The relative advantages and disadvantages of these are presented in Table 3.
Table 3.
Protect the Wound from Bacteria and Foreign Material | Absorb Exudate from the Wound | Prevent Heat and Fluid Loss from the Wound | Provide Compression to Minimize Edema and Obliterate Dead Space | Be Nonadherent and Removable without Causing Trauma | Create a Warm, Moist Occluded Environment | Cover an Unsightly Wound | Minimize Pain | Cost-Effectiveness | |
---|---|---|---|---|---|---|---|---|---|
Ointment only | + | − | − | − | ++ | + | − | − | +++ |
Ointment and gauze supported by tape | ++ | ++ | − | ++ | − | + | + | − | ++ |
Ointment and Telfa | ++ | + | − | + | +/− | + | + | − | ++ |
Films | +++ | − | + | − | − | + | − | + | ++ |
Four-layer technique with tape | ++ | + | ++ | ++ | +/− | + | + | − | + |
Four-layer technique with film | +++ | + | +++ | + | +/− | +++ | + | + | − |
Conclusion
At this time, the literature does not show conclusive differences in infection rate and cosmesis between the dressings discussed above in relation to simple sutured facial lacerations closed primarily. Topical ointment alone is a reasonable choice because it is cost-effective, maintains moisture, provides direct visualization of the wound, and simplifies care. Additionally, no unsightly dressings are visible. Selection of a dressing becomes more critical when further cautionary efforts are warranted, such as with young children and dirty occupational environments. If a dressing is chosen, the necessity for occlusion in simple facial lacerations is unknown. However, Hutchinson and McGuckin found wound infection was lower in occluded (2.6%) than in nonoccluded wounds (7.2%).36 Though untested, the four-layer technique (Steri-strips, antibiotic ointment, Telfa, and Tegaderm) seems to possess the most qualities of an ideal dressing, should the clinician prefer to use a dressing.
SYSTEMIC ANTIBIOTICS
It has been established by meta-analysis that systemic antibiotics do not reduce the incidence of infection for simple lacerations.51 Furthermore, the head and neck region has a lower incidence of infection with soft tissue trauma.21,52,53 Many consider that systemic antibiotics are ineffective for simple lacerations and that even if they were given, the potential benefits do not outweigh the associated costs and risks. However, certain subgroups of wounds and populations should receive greater consideration for systemic antibiotics. If the decision is made to provide systemic antibiotics, a first-generation cephalosporin or penicillinase-resistant penicillin is recommended. If allergic to penicillin, then clindamycin is recommended.38,54
Bite Wounds
Dog, cat, and human bite wounds are typically polymicrobial, containing aerobic and anaerobic organisms.55 The evidence for use of systemic antibiotics for mammalian bite wounds is conflicting. A meta-analysis of eight randomized trials revealed that systemic antibiotics reduce the incidence of infection in patients with dog bite wounds.56 Although cat bite wounds are more prone to infection,57 there are limited studies on the usage of systemic antibiotics for cat bite wounds.58,59,60 In contrast, Medeiros and Saconato's Cochrane review states there is no evidence that use of systemic antibiotics is effective for dog or cat bite wounds.61
Rittner and colleagues reviewed the best available evidence for human bite wounds and recommended that systemic antibiotics should be given if bites penetrate deeper than the epidermal layer, especially those involving skin overlying joints or cartilaginous structures.62
The current literature on facial bite wounds is limited, and we are unaware of well-designed prospective studies. One retrospective study concluded that routine systemic antibiotic use is not justified for animal bite wounds to the face.63 However, the data were of relatively low power without statistical significance and were generated from a series of case reports. Until further studies on head and neck bite wounds surface, we recommend systemic antibiotics for bite wounds.
The recommended antibiotic of choice is amoxicillin-clavulanic acid for dog, cat, and human bite wounds.55,64,65,66,67,68,69,70 For patients allergic to penicillin, clindamycin in combination with ciprofloxacin for adults or trimethoprim-sulfamethoxazole for children can be used.70 Moxifloxacin has also been shown to provide adequate coverage.55,71,72
Wounds Involving the Oral Cavity
Mark and Granquist performed an evidence-based review and found that at this time, studies have not shown statistically significant differences in the incidence of infection with systemic oral antibiotics versus placebo.73 Studies on this issue have not had enough power to yield statistically significant differences, though trends indicate a decrease in the rate of infection if patients comply with antibiotic regimens.74 There have been no specific studies on the necessity of systemic antibiotics for lacerations of the tongue, besides a report showing no infection in 28 children who did not receive antibiotics.75 Evidence-based conclusions have not been made for through-and-through lacerations of the lips and cheeks. Traditional thought is that antibiotics should be considered when a superficial skin laceration extends into the oral cavity.76 One commonly cited study for through-and-through lacerations only shows trends but does not provide conclusive evidence.74 Treatment decisions for all types of lacerations involving the oral cavity therefore must be guided by clinical judgment.73 If the oronasal mucosa is involved in the wound, the Streptococcus viridans group are the likely infectious organisms, and a first-generation cephalosporin or amoxicillin is recommended.38
Lacerations in Patients at Highest Risk of Adverse Outcomes from Infective Endocarditis or Those with Prosthetics Joints
According to the American Heart Association, those “patients with underlying cardiac conditions associated with the highest risk of adverse outcome from infective endocarditis . . . who undergo a surgical procedure that involve infected skin, skin structure, or musculoskeletal tissue,” it is reasonable to provide systemic antibiotics.77 Dermatologic literature goes on to recommend systemic antibiotics for contaminated wounds, such as traumatic lacerations, in those individuals at risk for infective endocarditis and with prosthetic joints.78 The choice of antibiotics should contain an active agent against staphylococci and β-hemolytic streptococci, such as a first-generation cephalosporin or penicillinase-resistant penicillin.77
Additional Subgroups
Patients at higher risk for infection include those with increasing age, conditions associated with immunocompromise (i.e., diabetes mellitus, HIV, chemotherapy, etc.), puncture wounds, the presence of foreign bodies, heavy contamination, jagged wound edges, injury deeper than the subcutaneous layer, wide lacerations, and delayed closure and those involving open fractures and joint wounds.53,79,80,81,82,83,84 One should consider the use of systemic antibiotics in such patients.
Conclusion
Systemic antibiotics should not necessarily be employed as a routine component of postoperative care of patients with facial lacerations. However, there are times when they may be required. Table 4 lists recommendations based upon what literature currently exists concerning their use.
Table 4.
Type of Wound | Systemic Antibiotics |
---|---|
Simple laceration | Do not recommend |
Bite wounds | Recommend |
Wounds involving oral cavity and through-and-through lacerations | Employ clinical judgment |
Patients at high risk of adverse outcomes from infective endocarditis or those with prosthetic joints | Recommend |
High-risk category | Strong consideration |
CLEANSING
If the wound is kept moist to prevent formation of a scab and is not grossly contaminated with debris, cleansing has not been shown to have an effect on infection rates or wound healing14,85 and therefore may not be necessary. The goal of cleansing the wound is to remove scab and debris and to decrease bacterial numbers to provide an optimal healing environment. If deemed necessary, the ideal cleansing agent should have a wide range of antimicrobial activity, persistent antibacterial effect, and minimum toxicity or adverse effects.38 Unfortunately, none of the commonly used cleansing agents fulfill all three of these criteria.
Clinicians recommend various cleansing solutions including hydrogen peroxide, saline, and tap water. A sterile cotton-tipped applicator soaked in diluted hydrogen peroxide has traditionally been used86 and is still employed by many (most?) clinicians today. Some prefer sterile saline or tap water, and others recommend that wounds healing by primary intention rarely require cleansing.85,86 There is also debate on whether wounds can get wet in the immediate postoperative period.
What follows is a review of what has been scientifically demonstrated about the most commonly used cleansing agents for postoperative wound care of simple soft tissue lacerations.
Hydrogen Peroxide
Hydrogen peroxide is widely used by clinicians because of its effervescent and presumed antimicrobial effects. The effervescent action is the result of oxygen bubbles created by the breakdown of hydrogen peroxide to water and oxygen by tissue catalase.87 The “bubbling” action may enhance mechanical cleansing of necrotic debris from wounds in inaccessible areas.88 However, studies have shown that hydrogen peroxide has relatively weak antimicrobial activity.26,87 Interestingly, methicillin-resistant S. aureus has been shown to be susceptible to 3% hydrogen peroxide in vitro.89,90,91
Recently, hydrogen peroxide has decreased in popularity due to its deleterious effects on wound healing.92,93,94 Adverse effects include inhibition of keratocyte migration and proliferation,95 formation of bullae under new epithelium,88 decreased wound tensile strength,17 and impaired fibroblast activity.96 Hydrogen peroxide also can prematurely degrade fast-absorbing gut suture, which may subsequently lead to widened or hypertrophic scarring.97
Tap Water and Saline
Tap water and saline are two other commonly used cleansing agents. For cost-effective reasons, it has been debated whether tap water can be used as an alternative for saline without an increase in infection rates. The potential advantage of saline is that it is isotonic and it is usually sterile. Tap water is neither of these. Angerås et al compared infection rates in simple soft tissue wounds irrigated with tap water at 37°C and normal saline at room temperature prior to repair. There was a lower infection rate (p = 0.04) in the tap water group compared with the saline group, but it is unclear why this was found.98 Theoretically, it could be a temperature-mediated change in local blood flow because the tap water was warmed to body temperature prior to use, whereas the saline was room temperature. It could also be the antimicrobial effect of chlorine in the tap water. Other studies in children and adults have found no statistically significant differences in infection rates between saline and tap water for irrigation of simple soft tissue wounds (prior to closure).99,100,101 Meta-analysis of these studies report that the possibility of harm from the use of tap water cannot be completely excluded and that the quality of water, the nature of the wound, and the patient's general condition should be considered.102 Although these studies evaluated cleansing with tap water and saline in open wounds prior to repair, it is reasonable to assume that continued use of tap water in the postoperative period is an acceptable alternative.
Showering
Showering in the postoperative period has been proven by meta-analysis to have no significant effect on infection rate and wound healing when compared with keeping the wound dry.102 Goldberg and colleagues' study of head and neck lacerations and surgical wounds found no difference in wound healing and infection rates when patients were allowed to shower after the first night versus keeping the wounds completely dry.85 Furthermore, a randomized controlled trial demonstrated that wounds allowed to get wet in the shower after the first 12 hours did not increase the incidence of infection.103 Consideration should be given to the patient's feeling of well-being that is preserved with ability to shower.85,104 Patients should be informed that showering after the first night is not detrimental to the healing wound. Currently, there are no studies to indicate if showering immediately is detrimental.
Conclusion
Hydrogen peroxide, saline, and tap water as cleansing agents have been used85 and continue to be described in texts.35,38,79,86,92,93,94 There is minimal literature to date that provides substantial evidence-based guidelines favoring one cleansing agent over another. To our knowledge, there have been no studies that have compared the difference between hydrogen peroxide, saline, tap water, and no cleansing on infection rates, wound healing, and cosmesis. The use of hydrogen peroxide seems to be driven mainly by clinical preference; however, the available evidence does not clearly show an optimal risk-to-benefit ratio. Tap water may serve as an alternative to hydrogen peroxide and saline because it is cost-effective, is readily available, simplifies postoperative wound care, and has no demonstrated difference on infection rates and wound healing. Prudence, however, would dictate that if the clinician chooses to cleanse a postoperative wound for the purpose of scab removal, debridement, and so on, one use a sterile solution. However, allowing tap water to rinse the area, such as with showering, is not detrimental.
FINAL CONCLUSIONS
Though based on known evidence, the following guidelines have not all been proven in multiple randomized clinical trials. For example, the four-layer dressing technique features many of the ideal characteristics of a dressing; however, it has not been compared with other options, including no dressing, for infection rates and optimal cosmesis. Randomized controlled trials must be conducted to further standardize the postoperative protocol for simple facial lacerations.
GUIDELINES
Use proper primary closure technique.
Apply Steri-strips with mastisol for the first several weeks if possible (Fig. 1A).
Apply topical antibiotic ointment for the first 2 days, after which petrolatum should be used to maintain moisture (Fig. 1B).
If using a dressing, then the four-layer technique dressing (Steri-strips, topical ointment, Telfa, and film) should be utilized (Figs. 1C and 1D).
Only certain scenarios dictate prescription of systemic antibiotics for simple facial lacerations.
Encourage daily showering after the first night.
If cleansing is necessary, use sterile saline to remove debris and scab.
Follow standard protocol for suture removal (4 to 5 days).
References
- Yavuzer R, Kelly C, Durrani N, Mittal V, Jackson I T, Remine S. Reinforcement of subcuticular continuous suture closure with surgical adhesive strips and gum mastic: is there any additional strength provided? Am J Surg. 2005;189:315–318. doi: 10.1016/j.amjsurg.2005.01.003. [DOI] [PubMed] [Google Scholar]
- Moy R L, Quan M B. An evaluation of wound closure tapes. J Dermatol Surg Oncol. 1990;16:721–723. doi: 10.1111/j.1524-4725.1990.tb00110.x. [DOI] [PubMed] [Google Scholar]
- Rodeheaver G T, McLane M, West L, Edlich R F. Evaluation of surgical tapes for wound closure. J Surg Res. 1985;39:251–257. doi: 10.1016/0022-4804(85)90150-7. [DOI] [PubMed] [Google Scholar]
- Mikhail G R, Selak L, Salo S, Balle M R. The efficacy of adhesives in the application of wound dressings. J Burn Care Rehabil. 1989;10:216–219. doi: 10.1097/00004630-198905000-00006. [DOI] [PubMed] [Google Scholar]
- Mikhail G R, Selak L, Salo S. Reinforcement of surgical adhesive strips. J Dermatol Surg Oncol. 1986;12:904–905. 908. doi: 10.1111/j.1524-4725.1986.tb02128.x. [DOI] [PubMed] [Google Scholar]
- Katz K H, Desciak E B, Maloney M E. The optimal application of surgical adhesive tape strips. Dermatol Surg. 1999;25:686–688. doi: 10.1046/j.1524-4725.1999.99084.x. [DOI] [PubMed] [Google Scholar]
- Werther J R, Freeman J P. Biologic basis of primary wound care. Oral Maxillofac Surg Clin North Am. 1996;8:563. [Google Scholar]
- Levenson S M, Crowley L V, Geever E F, Rosen H, Berard C W. Some studies of wound healing: experimental methods, effect of ascorbic acid and effect of deuterium oxide. J Trauma. 1964;4:543–566. doi: 10.1097/00005373-196409000-00001. [DOI] [PubMed] [Google Scholar]
- Leyden J J, Kligman A M. Rationale for topical antibiotics. Cutis. 1978;22:515–520. 522–528. [PubMed] [Google Scholar]
- Howell J M, Chisholm C D. Outpatient wound preparation and care: a national survey. Ann Emerg Med. 1992;21:976–981. doi: 10.1016/s0196-0644(05)82938-5. [DOI] [PubMed] [Google Scholar]
- Jones M E, Karlowsky J A, Draghi D C, Thornsberry C, Sahm D F, Nathwani D. Epidemiology and antibiotic susceptibility of bacteria causing skin and soft tissue infections in the USA and Europe: a guide to appropriate antimicrobial therapy. Int J Antimicrob Agents. 2003;22:406–419. doi: 10.1016/s0924-8579(03)00154-7. [DOI] [PubMed] [Google Scholar]
- Leyden J J. Effect of bacteria on healing of superficial wounds. Clin Dermatol. 1984;2:81–85. doi: 10.1016/0738-081x(84)90029-4. [DOI] [PubMed] [Google Scholar]
- Woodley D T, Chen J D, Kim J P, et al. Re-epithelialization. Human keratinocyte locomotion. Dermatol Clin. 1993;11:641–646. [PubMed] [Google Scholar]
- Robinson J KHC, Sengelmann R D, Siegel D M. In: Surgery of the Skin: Procedural Dermatology. Portland, OR: Elsevier Health Sciences; 2005. Dressings/post-op care. [Google Scholar]
- Schauerhamer R A, Edlich R F, Panek P, Thul J, Prusak M, Wangensteen O H. Studies in the management of the contaminated wound. VII. Susceptibility of surgical wounds to postoperative surface contamination. Am J Surg. 1971;122:74–77. doi: 10.1016/0002-9610(71)90352-7. [DOI] [PubMed] [Google Scholar]
- Winter G D. Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. Nature. 1962;193:293–294. doi: 10.1038/193293a0. [DOI] [PubMed] [Google Scholar]
- Hinman C D, Maibach H. Effect of air exposure and occlusion on experimental human skin wounds. Nature. 1963;200:377–378. doi: 10.1038/200377a0. [DOI] [PubMed] [Google Scholar]
- Dyson M, Young S, Pendle C L, Webster D F, Lang S M. Comparison of the effects of moist and dry conditions on dermal repair. J Invest Dermatol. 1988;91:434–439. doi: 10.1111/1523-1747.ep12476467. [DOI] [PubMed] [Google Scholar]
- Dyson M, Young S R, Hart J, Lynch J A, Lang S. Comparison of the effects of moist and dry conditions on the process of angiogenesis during dermal repair. J Invest Dermatol. 1992;99:729–733. doi: 10.1111/1523-1747.ep12614460. [DOI] [PubMed] [Google Scholar]
- Geronemus R G, Mertz P M, Eaglstein W H. Wound healing. The effects of topical antimicrobial agents. Arch Dermatol. 1979;115:1311–1314. doi: 10.1001/archderm.115.11.1311. [DOI] [PubMed] [Google Scholar]
- Dire D J, Coppola M, Dwyer D A, Lorette J J, Karr J L. Prospective evaluation of topical antibiotics for preventing infections in uncomplicated soft-tissue wounds repaired in the ED. Acad Emerg Med. 1995;2:4–10. doi: 10.1111/j.1553-2712.1995.tb03070.x. [DOI] [PubMed] [Google Scholar]
- Hirschmann J V. Topical antibiotics in dermatology. Arch Dermatol. 1988;124:1691–1700. [PubMed] [Google Scholar]
- Mack R M, Cantrell J R. Quantitative studies of the bacterial flora of open skin wounds: the effect of topical antibiotics. Ann Surg. 1967;166:886–895. doi: 10.1097/00000658-196712000-00002. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smack D P, Harrington A C, Dunn C, et al. Infection and allergy incidence in ambulatory surgery patients using white petrolatum vs bacitracin ointment. A randomized controlled trial. JAMA. 1996;276:972–977. [PubMed] [Google Scholar]
- Elston D M. Topical antibiotics in dermatology: emerging patterns of resistance. Dermatol Clin. 2009;27:25–31. doi: 10.1016/j.det.2008.07.004. [DOI] [PubMed] [Google Scholar]
- Lineaweaver W, Howard R, Soucy D, et al. Topical antimicrobial toxicity. Arch Surg. 1985;120:267–270. doi: 10.1001/archsurg.1985.01390270007001. [DOI] [PubMed] [Google Scholar]
- Tatnall F M, Rycroft R J. Pityriasis versicolor with cutaneous atrophy induced by topical steroid application. Clin Exp Dermatol. 1985;10:258–261. doi: 10.1111/j.1365-2230.1985.tb00567.x. [DOI] [PubMed] [Google Scholar]
- Leyden J J, Stewart R, Kligman A M. Updated in vivo methods for evaluating topical antimicrobial agents on human skin. J Invest Dermatol. 1979;72:165–170. doi: 10.1111/1523-1747.ep12676347. [DOI] [PubMed] [Google Scholar]
- Gette M T, Marks J G, Jr, Maloney M E. Frequency of postoperative allergic contact dermatitis to topical antibiotics. Arch Dermatol. 1992;128:365–367. [PubMed] [Google Scholar]
- Zug K A, Warshaw E M, Fowler J F, Jr, et al. Patch-test results of the North American Contact Dermatitis Group 2005–2006. Dermatitis. 2009;20:149–160. [PubMed] [Google Scholar]
- Marks J G, Jr, Belsito D V, DeLeo V A, et al. North American Contact Dermatitis Group North American Contact Dermatitis Group patch-test results, 1998 to 2000. Am J Contact Dermat. 2003;14:59–62. [PubMed] [Google Scholar]
- Brown C D, Zitelli J A. Choice of wound dressings and ointments. Otolaryngol Clin North Am. 1995;28:1081–1091. [PubMed] [Google Scholar]
- Lio P A, Kaye E T. Topical antibacterial agents. Infect Dis Clin North Am. 2004;18:717–733. doi: 10.1016/j.idc.2004.04.008. [DOI] [PubMed] [Google Scholar]
- Spann C T, Tutrone W D, Weinberg J M, Scheinfeld N, Ross B. Topical antibacterial agents for wound care: a primer. Dermatol Surg. 2003;29:620–626. doi: 10.1046/j.1524-4725.2003.29143.x. [DOI] [PubMed] [Google Scholar]
- Leach J. Proper handling of soft tissue in the acute phase. Facial Plast Surg. 2001;17:227–238. doi: 10.1055/s-2001-18825. [DOI] [PubMed] [Google Scholar]
- Hutchinson J J, McGuckin M. Occlusive dressings: a microbiologic and clinical review. Am J Infect Control. 1990;18:257–268. doi: 10.1016/0196-6553(90)90167-q. [DOI] [PubMed] [Google Scholar]
- Hutchinson J J, Lawrence J C. Wound infection under occlusive dressings. J Hosp Infect. 1991;17:83–94. doi: 10.1016/0195-6701(91)90172-5. [DOI] [PubMed] [Google Scholar]
- Cho C Y, Lo J S. Dressing the part. Dermatol Clin. 1998;16:25–47. doi: 10.1016/s0733-8635(05)70485-x. [DOI] [PubMed] [Google Scholar]
- Hess C T. How to use gauze dressings. Nursing. 2000;30:88. doi: 10.1097/00152193-200030090-00035. [DOI] [PubMed] [Google Scholar]
- Richardson M. The benefits of larval therapy in wound care. Nurs Stand. 2004;19:70, 72–74 passim. doi: 10.7748/ns.19.7.70.s60. [DOI] [PubMed] [Google Scholar]
- Jones A M, San Miguel L. Are modern wound dressings a clinical and cost-effective alternative to the use of gauze? J Wound Care. 2006;15:65–69. doi: 10.12968/jowc.2006.15.2.26886. [DOI] [PubMed] [Google Scholar]
- Fonder M A, Mamelak A J, Lazarus G S, Chanmugam A. Occlusive wound dressings in emergency medicine and acute care. Emerg Med Clin North Am. 2007;25:235–242. doi: 10.1016/j.emc.2007.01.012. [DOI] [PubMed] [Google Scholar]
- Wiseman D M, Rovee D T, Alvarez O M. Wound dressings: design and use. In: In: Cohen IR, Diegelman RF, Lindblad WJ, editor. Wound Healing: Biochemical and Clinical Aspects. Philadelphia: WB Saunders; 1992. pp. 562–579. [Google Scholar]
- Madden M R, Nolan E, Finkelstein J L, et al. Comparison of an occlusive and a semi-occlusive dressing and the effect of the wound exudate upon keratinocyte proliferation. J Trauma. 1989;29:924–930. discussion 930–931. doi: 10.1097/00005373-198907000-00004. [DOI] [PubMed] [Google Scholar]
- Katz M H, Alvarez A F, Kirsner R S, Eaglstein W H, Falanga V. Human wound fluid from acute wounds stimulates fibroblast and endothelial cell growth. J Am Acad Dermatol. 1991;25(6 Pt 1):1054–1058. doi: 10.1016/0190-9622(91)70306-m. [DOI] [PubMed] [Google Scholar]
- Varghese M C, Balin A K, Carter D M, Caldwell D. Local environment of chronic wounds under synthetic dressings. Arch Dermatol. 1986;122:52–57. [PubMed] [Google Scholar]
- Knighton D R, Silver I A, Hunt T K. Regulation of wound-healing angiogenesis-effect of oxygen gradients and inspired oxygen concentration. Surgery. 1981;90:262–270. [PubMed] [Google Scholar]
- Alvarez O M, Mertz P M, Eaglstein W H. The effect of occlusive dressings on collagen synthesis and re-epithelialization in superficial wounds. J Surg Res. 1983;35:142–148. doi: 10.1016/0022-4804(83)90136-1. [DOI] [PubMed] [Google Scholar]
- Rubio P A. Closure of abdominal wounds with continuous nonabsorbable sutures: experience in 1697 cases. Int Surg. 1991;76:159–160. [PubMed] [Google Scholar]
- Lionelli G TLW, Lawrence W T. Wound dressings. Surg Clin North Am. 2003;83:617–638. doi: 10.1016/S0039-6109(02)00192-5. [DOI] [PubMed] [Google Scholar]
- Cummings P, Del Beccaro M A. Antibiotics to prevent infection of simple wounds: a meta-analysis of randomized studies. Am J Emerg Med. 1995;13:396–400. doi: 10.1016/0735-6757(95)90122-1. [DOI] [PubMed] [Google Scholar]
- Lammers R L, Hudson D L, Seaman M E. Prediction of traumatic wound infection with a neural network-derived decision model. Am J Emerg Med. 2003;21:1–7. doi: 10.1053/ajem.2003.50026. [DOI] [PubMed] [Google Scholar]
- Hollander J E, Singer A J, Valentine S M, Shofer F S. Risk factors for infection in patients with traumatic lacerations. Acad Emerg Med. 2001;8:716–720. doi: 10.1111/j.1553-2712.2001.tb00190.x. [DOI] [PubMed] [Google Scholar]
- Moran E, Masters S, Berendt A R, McLardy-Smith P, Byren I, Atkins B L. Guiding empirical antibiotic therapy in orthopaedics: the microbiology of prosthetic joint infection managed by debridement, irrigation and prosthesis retention. J Infect. 2007;55:1–7. doi: 10.1016/j.jinf.2007.01.007. [DOI] [PubMed] [Google Scholar]
- Talan D A, Abrahamian F M, Moran G J, Citron D M, Tan J O, Goldstein E J, Emergency Medicine Human Bite Infection Study Group Clinical presentation and bacteriologic analysis of infected human bites in patients presenting to emergency departments. Clin Infect Dis. 2003;37:1481–1489. doi: 10.1086/379331. [DOI] [PubMed] [Google Scholar]
- Cummings P. Antibiotics to prevent infection in patients with dog bite wounds: a meta-analysis of randomized trials. Ann Emerg Med. 1994;23:535–540. doi: 10.1016/s0196-0644(94)70073-7. [DOI] [PubMed] [Google Scholar]
- Smith P F, Meadowcroft A M, May D B. Treating mammalian bite wounds. J Clin Pharm Ther. 2000;25:85–99. doi: 10.1046/j.1365-2710.2000.00274.x. [DOI] [PubMed] [Google Scholar]
- Dire D J, Hogan D E, Walker J S. Prophylactic oral antibiotics for low-risk dog bite wounds. Pediatr Emerg Care. 1992;8:194–199. doi: 10.1097/00006565-199208000-00005. [DOI] [PubMed] [Google Scholar]
- Elenbaas R M, McNabney W K, Robinson W A. Evaluation of prophylactic oxacillin in cat bite wounds. Ann Emerg Med. 1984;13:155–157. doi: 10.1016/s0196-0644(84)80604-6. [DOI] [PubMed] [Google Scholar]
- Stefanopoulos P K, Tarantzopoulou A D. Facial bite wounds: management update. Int J Oral Maxillofac Surg. 2005;34:464–472. doi: 10.1016/j.ijom.2005.04.001. [DOI] [PubMed] [Google Scholar]
- Medeiros I, Saconato H. Antibiotic prophylaxis for mammalian bites. Cochrane Database Syst Rev. 2001;(2):CD001738. doi: 10.1002/14651858.CD001738. [DOI] [PubMed] [Google Scholar]
- Rittner A V, Fitzpatrick K, Corfield A. Best evidence topic report. Are antibiotics indicated following human bites? Emerg Med J. 2005;22:654. doi: 10.1136/emj.2005.028662. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wolff K D. Management of animal bite injuries of the face: experience with 94 patients. J Oral Maxillofac Surg. 1998;56:838–843. discussion 843–844. doi: 10.1016/s0278-2391(98)90009-x. [DOI] [PubMed] [Google Scholar]
- Goldstein F W. Choice of an oral beta-lactam antibiotic for infections due to penicillin-resistant Streptococcus pneumoniae. Scand J Infect Dis. 1997;29:255–257. doi: 10.3109/00365549709019038. [DOI] [PubMed] [Google Scholar]
- Goldstein E J, Nesbit C A, Citron D M. Comparative in vitro activities of azithromycin, Bay y 3118, levofloxacin, sparfloxacin, and 11 other oral antimicrobial agents against 194 aerobic and anaerobic bite wound isolates. Antimicrob Agents Chemother. 1995;39:1097–1100. doi: 10.1128/aac.39.5.1097. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goldstein E J, Citron D M. Comparative susceptibilities of 173 aerobic and anaerobic bite wound isolates to sparfloxacin, temafloxacin, clarithromycin, and older agents. Antimicrob Agents Chemother. 1993;37:1150–1153. doi: 10.1128/aac.37.5.1150. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goldstein E J, Citron D M, Merriam C V, Tyrrell K, Warren Y. Activity of gatifloxacin compared to those of five other quinolones versus aerobic and anaerobic isolates from skin and soft tissue samples of human and animal bite wound infections. Antimicrob Agents Chemother. 1999;43:1475–1479. doi: 10.1128/aac.43.6.1475. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goldstein E J, Citron D M, Hunt Gerardo S, Hudspeth M, Merriam C V. Comparative in vitro activities of DU-6859a, levofloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against 387 aerobic and anaerobic bite wound isolates. Antimicrob Agents Chemother. 1997;41:1193–1195. doi: 10.1128/aac.41.5.1193. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fleisher G R. The management of bite wounds. N Engl J Med. 1999;340:138–140. doi: 10.1056/NEJM199901143400210. [DOI] [PubMed] [Google Scholar]
- Talan D A, Citron D M, Abrahamian F M, Moran G J, Goldstein E J, Emergency Medicine Animal Bite Infection Study Group Bacteriologic analysis of infected dog and cat bites. N Engl J Med. 1999;340:85–92. doi: 10.1056/NEJM199901143400202. [DOI] [PubMed] [Google Scholar]
- Goldstein E J, Citron D M, Merriam C V, Warren Y A, Tyrrell K L, Fernandez H. In vitro activities of the des-fluoro(6) Quinolone BMS-284756 against aerobic and anaerobic pathogens isolated from skin and soft tissue animal and human bite wound infections. Antimicrob Agents Chemother. 2002;46:866–870. doi: 10.1128/AAC.46.3.866-870.2002. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goldstein E J, Citron D M, Merriam C V, Warren Y A, Tyrrell K L, Fernandez H T. Comparative in vitro activity of faropenem and 11 other antimicrobial agents against 405 aerobic and anaerobic pathogens isolated from skin and soft tissue infections from animal and human bites. J Antimicrob Chemother. 2002;50:411–420. doi: 10.1093/jac/dkf139. [DOI] [PubMed] [Google Scholar]
- Mark D G, Granquist E J. Are prophylactic oral antibiotics indicated for the treatment of intraoral wounds? Ann Emerg Med. 2008;52:368–372. doi: 10.1016/j.annemergmed.2007.12.028. [DOI] [PubMed] [Google Scholar]
- Steele M T, Sainsbury C R, Robinson W A, Salomone J A, III, Elenbaas R M. Prophylactic penicillin for intraoral wounds. Ann Emerg Med. 1989;18:847–852. doi: 10.1016/s0196-0644(89)80210-0. [DOI] [PubMed] [Google Scholar]
- Lamell C W, Fraone G, Casamassimo P S, Wilson S. Presenting characteristics and treatment outcomes for tongue lacerations in children. Pediatr Dent. 1999;21:34–38. [PubMed] [Google Scholar]
- Soft E E. Tissue and Dentoalveolar Injuries. 5th ed. St. Louis: Mosby; 2008.
- Wilson W, Taubert K A, Gewitz M, et al. American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee. American Heart Association Council on Cardiovascular Disease in the Young. American Heart Association Council on Clinical Cardiology. American Heart Association Council on Cardiovascular Surgery and Anesthesia. Quality of Care and Outcomes Research Interdisciplinary Working Group Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation. 2007;116:1736–1754. doi: 10.1161/CIRCULATIONAHA.106.183095. [DOI] [PubMed] [Google Scholar]
- Babcock M D, Grekin R C. Antibiotic use in dermatologic surgery. Dermatol Clin. 2003;21:337–348. doi: 10.1016/s0733-8635(02)00096-7. [DOI] [PubMed] [Google Scholar]
- Singer A J, Hollander J E, Quinn J V. Evaluation and management of traumatic lacerations. N Engl J Med. 1997;337:1142–1148. doi: 10.1056/NEJM199710163371607. [DOI] [PubMed] [Google Scholar]
- Cruse P J, Foord R. A five-year prospective study of 23,649 surgical wounds. Arch Surg. 1973;107:206–210. doi: 10.1001/archsurg.1973.01350200078018. [DOI] [PubMed] [Google Scholar]
- Patzakis M J, Harvey J P, Jr, Ivler D. The role of antibiotics in the management of open fractures. J Bone Joint Surg Am. 1974;56:532–541. [PubMed] [Google Scholar]
- Patzakis M J, Wilkins J. Factors influencing infection rate in open fracture wounds. Clin Orthop Relat Res. 1989;(243):36–40. [PubMed] [Google Scholar]
- Nakamura Y, Daya M. Use of appropriate antimicrobials in wound management. Emerg Med Clin North Am. 2007;25:159–176. doi: 10.1016/j.emc.2007.01.007. [DOI] [PubMed] [Google Scholar]
- Gosselin R A, Roberts I, Gillespie W J. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. 2004;(1):CD003764. doi: 10.1002/14651858.CD003764.pub2. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goldberg H M, Rosenthal S A, Nemetz J C. Effect of washing closed head and neck wounds on wound healing and infection. Am J Surg. 1981;141:358–359. doi: 10.1016/0002-9610(81)90196-3. [DOI] [PubMed] [Google Scholar]
- Edlich R F, Sutton S T. Postrepair wound care revisited. Acad Emerg Med. 1995;2:2–3. doi: 10.1111/j.1553-2712.1995.tb03069.x. [DOI] [PubMed] [Google Scholar]
- Reed B R, Clark R A. Cutaneous tissue repair: practical implications of current knowledge. II. J Am Acad Dermatol. 1985;13:919–941. doi: 10.1016/s0190-9622(85)70242-3. [DOI] [PubMed] [Google Scholar]
- Gruber R P, Vistnes L, Pardoe R. The effect of commonly used antiseptics on wound healing. Plast Reconstr Surg. 1975;55:472–476. [PubMed] [Google Scholar]
- Warnke P H, Becker S T, Podschun R, et al. The battle against multi-resistant strains: renaissance of antimicrobial essential oils as a promising force to fight hospital-acquired infections. J Craniomaxillofac Surg. 2009;37:392–397. doi: 10.1016/j.jcms.2009.03.017. [DOI] [PubMed] [Google Scholar]
- French G L, Otter J A, Shannon K P, Adams N M, Watling D, Parks M J. Tackling contamination of the hospital environment by methicillin-resistant Staphylococcus aureus (MRSA): a comparison between conventional terminal cleaning and hydrogen peroxide vapour decontamination. J Hosp Infect. 2004;57:31–37. doi: 10.1016/j.jhin.2004.03.006. [DOI] [PubMed] [Google Scholar]
- Flournoy D J, Robinson M C. In vitro antimicrobial susceptibilities of 349 methicillin-resistant Staphylococcus aureus isolates from veterans. Methods Find Exp Clin Pharmacol. 1990;12:541–544. [PubMed] [Google Scholar]
- Patel P R, Miller M A. Postcare recommendations for emergency department wounds. Emerg Med Clin North Am. 2007;25:147–158. doi: 10.1016/j.emc.2007.01.006. [DOI] [PubMed] [Google Scholar]
- Brown C D, Zitelli J A. A review of topical agents for wounds and methods of wounding. Guidelines for wound management. J Dermatol Surg Oncol. 1993;19:732–737. doi: 10.1111/j.1524-4725.1993.tb00417.x. [DOI] [PubMed] [Google Scholar]
- Brown C DZJ. Choice of Wound Dressings and Ointments. Shelton, CT: BC Decker; 2009.
- O'Toole E A, Goel M, Woodley D T. Hydrogen peroxide inhibits human keratinocyte migration. Dermatol Surg. 1996;22:525–529. doi: 10.1111/j.1524-4725.1996.tb00368.x. [DOI] [PubMed] [Google Scholar]
- Tatnall F M, Leigh I M, Gibson J R. Comparative study of antiseptic toxicity on basal keratinocytes, transformed human keratinocytes and fibroblasts. Skin Pharmacol. 1990;3:157–163. doi: 10.1159/000210865. [DOI] [PubMed] [Google Scholar]
- Athre R S, Park J, Leach J L. The effect of a hydrogen peroxide wound care regimen on tensile strength of suture. Arch Facial Plast Surg. 2007;9:281–284. doi: 10.1001/archfaci.9.4.281. [DOI] [PubMed] [Google Scholar]
- Angerås M H, Brandberg A, Falk A, Seeman T. Comparison between sterile saline and tap water for the cleaning of acute traumatic soft tissue wounds. Eur J Surg. 1992;158:347–350. [PubMed] [Google Scholar]
- Bansal B C, Wiebe R A, Perkins S D, Abramo T J. Tap water for irrigation of lacerations. Am J Emerg Med. 2002;20:469–472. doi: 10.1053/ajem.2002.35501. [DOI] [PubMed] [Google Scholar]
- Valente J H, Forti R J, Freundlich L F, Zandieh S O, Crain E F. Wound irrigation in children: saline solution or tap water? Ann Emerg Med. 2003;41:609–616. doi: 10.1067/mem.2003.137. [DOI] [PubMed] [Google Scholar]
- Moscati R M, Mayrose J, Reardon R F, Janicke D M, Jehle D V. A multicenter comparison of tap water versus sterile saline for wound irrigation. Acad Emerg Med. 2007;14:404–409. doi: 10.1197/j.aem.2007.01.007. [DOI] [PubMed] [Google Scholar]
- Fernandez R, Griffiths R. Water for wound cleansing. Cochrane Database Syst Rev. 2008;(1):CD003861. doi: 10.1002/14651858.CD003861.pub2. [DOI] [PubMed] [Google Scholar]
- Heal C BP, Buettner P, Raasch B, et al. Can sutures get wet? Prospective randomised controlled trial of wound management in general practice. BMJ. 2006;332:1053–1056. doi: 10.1136/bmj.38800.628704.AE. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Neues C, Haas E. Modification of postoperative wound healing by showering. Chirurg. 2000;71:234–236. doi: 10.1007/s001040050040. [DOI] [PubMed] [Google Scholar]