Figure 4.

Photomicrographs of the contralateral kidney from a diabetic rat into which embryonic pig pancreas had been transplanted in mesentery and pig islets had been implanted subsequently in the other kidney (A–D) or of a kidney from a diabetic rat in which pig islets had been implanted without prior transplantation of E28 pig pancreatic primordia (E and F) stained using anti-insulin antibody (A, C and E) or control antibody (B, D and F). Arrowheads delineate a normal sized subcapsular space (A and C) or expanded subcapsular space (E). PT, proximal tubule (A, B, E and F). M, medulla (A and B). Scale bars 100 µm (A and B) 10 µm (C and D) or 40 µm (E and F). Reproduced with permission from the American Society for Investigative Pathology.¹²