Table III.
Comparison Between the Results Given by Wild-Type Sequences, Sequences Designed by RosettaDesign 2.3 and by RosettaDesign-SR
| % Polar residuesa |
||||||||
|---|---|---|---|---|---|---|---|---|
| Seq. ID (%)b | % LCc | % LLLd | % VVVe | All | α | β | Coil | |
| Wild-type | 100 | 3.1% | 0.063 | 0.045 | 50.1 | 51.8 | 44.7 | 52.5 |
| RosettaDesign | 31.4 | 9.1% | 0.244 | 0.093 | 45.6 | 50.1 | 36.1 | 48.3 |
| RosettaDesign-SR | 33.9 | 4.0% | 0.039 | 0.038 | 48.2 | 51.1 | 41.5 | 50.3 |
The results are obtained for the test set of 944 proteins with the top 1 ranked sequence in 100 sequences designed for each protein.
a
Frequency of polar residues for helical, strand, and coil positions, respectively.
b
The average sequence identity to wild type sequences of target proteins.
c
Percent of low-complexity regions defined by program SEG72
d
Percent of occurrence for three sequentially linked Leu residues.
e
Percent of occurrence for three sequentially linked Val residues.