Table 1.

IFN-γ and IL-8 release by the CD56⁺ and CD56⁻ lymphocytes

Stimulation	CD56+/CD14−				CD56−/CD14−
	6 hours		24 hours		6 hours		24 hours
	IFN-γ	IL-8	IFN-γ	IL-8	IFN-γ	IL-8	IFN-γ	IL-8
IL-12	0.94 ± 0.81	0.14 ± 0.02	0.07 ± 0.04	0.13 ± 0.01	1.52 ± 0.49	0.34 ± 0.02	0.21 ± 0.09	0.34 ± 0.05
IL-18	0.01 ± 0.02	0.14 ± 0.03	ND	0.52 ± 0.47	0.44 ± 0.08	0.36 ± 0.07	0.15 ± 0.06	0.47 ± 0.09
IL-12 + IL-18	3.29 ± 3.04	0.12 ± 0.01	126 ± 58.4	7.92 ± 5.38	0.33 ± 0.09	0.30 ± 0.11	11.3 ± 3.82	0.46 ± 0.07

The relative ability of the CD56⁺/CD14⁻ and the CD56⁻/CD14⁻ subpopulations of lymphocytes to express IFN-γ and IL-8 was measured by ELISA. Human lymphocytes were isolated from PBMCs after CD14 depletion, and 5 × 10⁶ cells were stimulated with rIL-12 (10 ng/mL) and rIL-18 (10 ng/mL) for 6 hours and 24 hours. The cell supernatants were analyzed for IFN-γ and IL-8 release. Values are mean ± SD for 2 experiments.

ND indicates not detected.