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. 1987 Oct 26;15(20):8511–8519. doi: 10.1093/nar/15.20.8511

Selective catalysis of A.T base pair proton exchange in DNA complexes: imino proton NMR analysis.

L Strekowski 1, R A Watson 1, W D Wilson 1
PMCID: PMC306374  PMID: 3671090

Abstract

Polyaromatic molecules with amino chain substituents, upon binding with DNA, selectively catalyze exchange of the A.T base pair protons with bulk water protons. The amine-catalyzed exchange is mediated by compounds which are A.T and G.C base sequence specific, intercalators, and outside binders. A mechanism for the selective exchange, involving transient opening and closing of individual A.T base pairs in the duplex, is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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