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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Cancer. 2010 Nov 8;117(7):1446–1453. doi: 10.1002/cncr.25665

Figure 2. Loss of heterozygosity analyses.

Figure 2

Panel A: PCR amplification products of marker rs1057035 in representative normal (N) / tumor (T) pairs digested with MwoI. Tumor 1870 demonstrates LOH (DICER1 expression = 2.38 arbitrary units).

Panel B: PCR amplification products of marker rs1209904 in representative normal (N) / tumor (T) pairs digested with HpyCH4IV. Tumors 1641 (DICER1 expression = 12.29 arbitrary units), 1870 (DICER1 expression = 2.38 arbitrary units) and 1907 (DICER1 expression = 0.48 arbitrary units) demonstrate allelic imbalance.

White arrows indicate the allelic fragment(s) with reduced intensity.