Table II.
Case-only interaction between apoptotic SNPs and GERD on EA risk
| SNPs | GERD |
ORia (95% CI) | Padja | |
| No, n (%) | Yes, n (%) | |||
| PERP rs651662 | ||||
| GG | 68 (41.97) | 43 (24.86) | reference | |
| GA + AA | 94 (58.03) | 130 (75.14) | 2.13 (1.33–3.40) | 0.02 |
| PERP rs648802 | ||||
| CC | 67 (41.36) | 43 (24.86) | reference | |
| CG + GG | 95 (58.64) | 130 (75.14) | 2.09 (1.30–3.34) | 0.02 |
| PIK3CA rs4855094 | ||||
| GG | 151 (93.21) | 145 (83.82) | reference | |
| GA + AA | 11 (6.79) | 28 (16.18) | 2.76 (1.32–5.80) | 0.04 |
| PIK3CA rs7644648 | ||||
| AA | 123 (75.93) | 109 (63.00) | reference | |
| GA + GG | 39 (24.07) | 64 (37.00) | 1.89 (1.17–3.06) | 0.04 |
| TNFRSF1A rs4149579 | ||||
| GG | 130 (80.25) | 157 (90.75) | reference | |
| GA + AA | 32 (19.76) | 16 (9.25) | 0.42 (0.22–0.81) | 0.04 |
| bCumulative risks of rs648802, rs4855094, rs76044648 and rs4149579 | ||||
| ≤1 risk genotype | 65 (40.12) | 37 (21.39) | reference | |
| 2 risk genotypes | 75 (46.30) | 82 (47.40) | 1.89 (1.13–3.16) | 0.016 |
| ≥3 risk genotypes | 22 (13.58) | 54 (31.21) | 4.30 (2.25–8.20) | <0.0001 |
a
Adjusted for age, sex, BMI at age 18 (<25 versus ≥25) and smoking (+/−) (also false discovery rate for Padj).
b
Since rs651662 and rs648802 were in linkage disequilibrium, only the later was used to calculate the cumulative risks.