Figure 3.

Neutrophil adhesion to TNF-α-stimulated HUVEC in the presence of integrin-specific blocking monoclonal antibody. Neutrophils (2x10⁶ cell/mL) from control individuals (A, n=4) or from SCD patients (B, n=5) were allowed to adhere to TNF-α-stimulated HUVEC for 30 min at 37°C, 5% CO₂, in the presence or absence of integrin-blocking monoclonal antibody, as indicated. *P<0.05; **P<0.01; ***P<0.001, compared to basal adhesion; Friedman’s test, followed by Dunn’s multiple comparison between selected groups and basal adhesion.