Figure 5.

Decorin reduces Sema3A expression by cultured leptomeningeal fibroblasts isolated from both brain and spinal cord meninges. The graph shows a significant reduction in the expression of Sema3A after decorin treatment of both spinal and brain leptomeningeal meningeal fibroblasts compared with saline-treated fibroblasts. Data are represented as relative quantitation of Sema3A expression compared with saline-treated control samples that were given a reference value of 1. Error bars = standard deviations. Decorin treatment resulted in reductions of 62.0% (±5.0) and 55.0% (±8.0) in Sema3A expression, respectively, compared with untreated cells.