Table 2.
Characteristics of adult patients with NAFLD with contemporaneous* biopsies and clinical factors by presence of definite NASH
| Variable | Presence of Definite NASHH | PI | |
|---|---|---|---|
| No (n=291) |
Yes (n=404) |
||
| Demographics | |||
| Male (%) | 45 | 34 | 0.006 |
| Age - yrs (median) | 48 | 49 | 0.57 |
| White (%) | 82 | 80 | 0.49 |
| Hispanic (%) | 13 | 15 | 0.48 |
| Clinical | |||
| Hypertension (%) | 40 | 47 | 0.07 |
| Type 2 diabetes (%) | 17 | 26 | 0.007 |
| Metabolic syndrome' (%) | 56 | 66 | 0.01 |
| Acanthosis nigricans positive (%) | 13 | 14 | 0.76 |
| severity score2 (mean) | 0.26 | 0.34 | 0.22 |
| Anthropometric (median) | |||
| Body mass index - kg/m2 | 33 | 34 | 0.87 |
| Waist circumference - cm | 108 | 109 | 0.51 |
| Waist to hip ratio | 0.93 | 0.94 | 0.53 |
| Hepatology panel (median) | |||
| AST - U/L | 37 | 55 | <0.0001 |
| ALT - U/L | 56 | 74 | <0.0001 |
| AST/ALT | 0.68 | 0.74 | 0.03 |
| Alkaline phosphatase - U/L | 78 | 83 | 0.05 |
| Isolated abnormal alkaline phosphatase& (%) | 5 | 2 | 0.01 |
| GGT - U/L | 40 | 56 | <0.0001 |
| Globulin - g/dL | 2.9 | 3.0 | 0.0004 |
| Albumin - g/dL | 4.2 | 4.2 | 0.18 |
| Bilirubin, total - mg/dL | 0.7 | 0.6 | 0.0007 |
| Bilirubin, direct- mg/dL | 0.1 | 0.1 | 0.41 |
| International normalized ratio (mean) | 1.01 | 1.03 | 0.22 |
| Hematology and other laboratory studies (median) | |||
| Hematocrit - % | 42 | 43 | 0.09 |
| White blood cells - 1K/mm3 | 6.7 | 6.8 | 0.61 |
| Platelet count - 1K/mm3 | 249 | 239 | 0.25 |
| Total cholesterol - mg/dL | 194 | 196 | 0.33 |
| HDL cholesterol - mg/dL | 43 | 41 | 0.01 |
| LDL cholesterol - mg/dL | 120 | 119 | 0.98 |
| Triglycerides - mg/dL | 137 | 159 | 0.01 |
| HbA1c - % | 5.6 | 5.7 | 0.0002 |
| Fasting serum glucose - mg/dL | 94 | 97 | 0.003 |
| Fasting serum insulin - µU/mL | 16 | 20 | 0.001 |
| HOMA-IR - mg/dLHΦU/mL/405 | 3.8 | 5.0 | <0.0001 |
| ANA (% positive) | 26 | 23 | 0.44 |
| ASMA (% positive) | 14 | 7 | 0.004 |
| ANA + ASMA (% both positive) | 5 | 1 | 0.0009 |
| AMA (% positive) | 4 | 8 | 0.06 |
| Ferritin - ng/mL | 129 | 174 | 0.003 |
| Histology | |||
| Steatosis (% ∃ 34%) | 50 | 66 | <0.0001 |
| Lobular inflammation (% ∃ grade 2) | 30 | 62 | <0.0001 |
| Portal inflammation (% > mild) | 13 | 25 | 0.0002 |
| Ballooning (% any) | 22 | 100 | <0.0001 |
| NAFLD Activity Score (% ∃ 5) | 16 | 73 | <0.0001 |
| Fibrosis - score** (mean) | 0.9 | 2.0 | <0.0001 |
| Mallory Denk bodies (% present) | 2 | 46 | <0.0001 |
| Biopsy length (% < 10 mm) | 19 | 9 | 0.0001 |
*
Within 6 months
H
3 patients with missing data for presence of NASH
I
Comparison of presence vs. absence of definite NASH using chi-square test for binary predictors and logistic regression of group indicator on continuous predictors
'
NCEP definition
2
0=absent, 1=present on close inspection, 2=mild, 3=moderate, 4=severe
&
Defined as alkaline phosphatase ∃ 1 ULN and AST < 1 ULN and ALT < 1 ULN according to local references ranges
**
Fibrosis scored 0 for none; 1 for mild to moderate in zone 3 perisinusoidal or portal/periportal only; 2 for zone 3 perisinusoidal and portal/periportal; 3 for bridging; and 4 for cirrhosis