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. 1995 Jul 25;23(14):2626–2628. doi: 10.1093/nar/23.14.2626

Trans-activation and DNA-binding properties of the transcription factor, Sox-18.

B M Hosking 1, G E Muscat 1, P A Koopman 1, D H Dowhan 1, T L Dunn 1
PMCID: PMC307084  PMID: 7651823

Abstract

Sox-18 is a member of the Sox multi-gene family (Sry-related HMG-box gene). We have bacterially expressed this 378 amino acid protein and demonstrated sequence-specific binding to the Sox DNA-binding motif AACAAAG. A distinct 95 amino acid activation domain was mapped in Sox-18 using GAL4-Sox-18 fusions (amino acids 160-225). Furthermore, Sox-18 was capable of trans-activating gene expression through the AACAAA motif. Our results suggest that Sox-18 functions as a classical trans-activator of gene expression.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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