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. 1995 Aug 11;23(15):3034–3040. doi: 10.1093/nar/23.15.3034

Whole genome amplification of single cells: mathematical analysis of PEP and tagged PCR.

F Sun 1, N Arnheim 1, M S Waterman 1
PMCID: PMC307146  PMID: 7659528

Abstract

We construct a mathematical model for two whole genome amplification strategies, primer extension preamplification (PEP) and tagged polymerase chain reaction (tagged PCR). An explicit formula for the expected target yield of PEP is obtained. The distribution of the target yield and the coverage properties of these two strategies are studied by simulations. From our studies we find that polymerase with high processivity may increase the efficiency of PEP and tagged PCR.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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