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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Surgery. 2011 Feb 5;149(4):484–495. doi: 10.1016/j.surg.2010.11.014

FIG. 5.

FIG. 5

Repeated L-A-5-RIP-TK administration induced anti-adenovirus antibodies. C57BL/6J mice without prior exposure to adenovirus were treated with naked A-5-RIP-TK or L-A-5-RIP-TK. Repeated naked A-5-RIP-TK or L-A-5-RIP-TK was administrated in a 3 weeks interval, 3 doses in total. 7days after each administration, the serum was collected for measurement of neutralized antibody. Either A-5-RIP-TK or L-A-5-RIP-TK induced high titer of anti adenoviral antibody. Repeated administration of adenovirus resulted in increased antibody titers.