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. 2010 May-Jun;1(3):156–163. doi: 10.4161/viru.1.3.11748

Table 1.

Pathologic changes induced by BCG, H37Ra or M. smegmatis in the rabbit skin model

Prime Boost
Live BCG 5 × 106 CFU Granuloma+++ (24–72 h)
Liquefaction and ulcer+++, 10–13 days later		 Ulcer++++, 3–7 days later;
Liquefaction++++
Live BCG 5 × 104 CFU Granuloma+ Granuloma+
Live BCG 5 × 102 CFU ± ±
Heat-killed BCG 5 × 106 CFU + +
Live H37Ra 5 × 106 CFU Granuloma++ (24–72 h)
Liquefaction and ulcer ±, 10–13 days later		 Ulcer++, 5–7 days later;
Liquefaction++
Live H37Ra 5 × 104 CFU ± ±
Live H37Ra 5 × 102 CFU − −
Heat-killed H37Ra 5 × 106 CFU + +
Live M. smegmatis 5 × 106 CFU Granuloma+ (24–72 h)
Liquefaction and ulcer ±, 10–13 days later		 Ulcer+, 7–9 days later;
Liquefaction++
Live M. smegmatis 5 × 104 CFU ± ±
Live M. smegmatis 5 × 102 CFU − −
Heat-killed M. smegmatis 5 × 106 CFU ± ±

Symbols: −, no granuloma, liquefaction and ulcer; ±, no obvious granuloma, liquefaction and ulcer; +∼++++, the number of plus represents the degree of pathologic changes.