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. Author manuscript; available in PMC: 2011 Oct 14.
Published in final edited form as: Nature. 2011 Mar 16;472(7342):234–237. doi: 10.1038/nature09854

Figure 4. Scm3 induces large conformational changes in Cse4 and H4 and prevents loop 2 of H4 from binding to DNA.

Figure 4

a, Cse4-H4 in scSCH. The extended α3 helix in H4 is shown in light green. The loop of Scm3 pushes loop 1 of Cse4 away from loop 2 of H4 and prevents loop 2 of H4 from binding to DNA. DNA is modeled to bind the loop 2 region of H4 based on the canonical nucleosome structure29. b, CENP-A-H4 in the (CENP-A-H4)2 tetramer. DNA is modeled to bind to loop 2 region of H4 based on the canonical nucleosome struture29.