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STAMPEDE design parameters.
| Stage (i) | Outcome | αi | ωi | δi | ei | ti |
|---|---|---|---|---|---|---|
| 1 | FFS | 0.5 | 0.95 | 1.00 | 113 | 3.0 |
| 2 | FFS | 0.25 | 0.95 | 0.92 | 213 | 4.4 |
| 3 | FFS | 0.1 | 0.95 | 0.89 | 331 | 5.8 |
| 4 | OS | 0.025 | 0.9 | 0.84 | 403 | 8.0 |
| Overall | 0.017 | 0.84* | ||||
| 0.012 | 0.83** | |||||
*Using corr. matrix R1
**Using corr. matrix R2
Time is expressed in years. Accrual rate (ri) was planned to be 348 patients per year in each stage. FFS = failure-free survival, OS = overall survival.
