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Attempted 1,6-conjugate addition on model compound.[a]
 | ||
|---|---|---|
| Entry | Conditions | Results |
| 1 | AcNHOAc, Cs2CO3, LA[b], CH3CN, rt-80 °C | NR[c] |
| 2 | nBuLi, AcNHOAc, THF, −40 °C-rt, | NR |
| 3 | (AcNOAc)2CuLi-LiCN, THF, -78-0 °C | NR |
| 4 | AcNHOAc, NaH, DMF, rt-90 °C | NR |
| 5 | BocNHOP(O)(OEt)2, NaH, DMF, rt −70 °C | NR |
Pg = protecting group.
LA= Pd(CH3CN)2Cl2, Sc(OTf)3, Yb(OTf)3, In(OTf)3, or Cu(OTf)3.
NR = no reaction.
