Table I.
DNA single- and double-strand breaks, alkali-labile sites (DNA damage) and oxidised bases (oxidative DNA damage) evaluated by comet assay in lymphocytes from patients exposed to surgery and ISF among the time points evaluated
| Tail intensity (%) |
P value | |||
| T1 | T2 | T3 | ||
| DNA damage | 19.0 (12.7–24.6) | 17.8 (11.1–28.1) | 18.5 (16.7–21.3) | 0.58 |
| Oxidised purinesa | 31.8 (21.7–38.6) | 29.6 (21.0–39.9) | 22.9 (21.3–29.9) | 0.31 |
| Oxidised pyrimidinesb | 22.3 (13.0–27.4) | 21.8 (15.5–26.9) | 14.5 (9.4–21.1) | 0.10 |
T1: before anaesthesia; T2: 2 h after the beginning of anaesthesia and T3: on the first post-operative day. Data, obtained from 20 subjects, are expressed as median and quartiles.
a
Determined as Fpg-sensitive sites.
b
Determined as endo III-sensitive sites.