Table 3.
Human epidermal growth factor receptor 2 (HER2) SP3 and 4B5 immunoscores versus (a) silver in situ hybridization (SISH), (b) fluorescence in situ hybridization (FISH)
| ISH | ISH | ||||||
|---|---|---|---|---|---|---|---|
| SP3 | Negative | Positive | Total | 4B5 | Negative | Positive | Total |
| (a) | |||||||
| 0 | 123 (98%) | 2 (2%) | 125 | 0 | 106 (100%) | 0 (0%) | 106 |
| 1+ | 1 (25%) | 3 (75%) | 4 | 1+ | 16 (94%) | 1 (6%) | 17 |
| 2+ | 0 (0%) | 6 (100%) | 6 | 2+ | 2 (33%) | 4 (66%) | 6 |
| 3+ | 0 (0%) | 11 (100%) | 11 | 3+ | 0 (0%) | 17 (100%) | 17 |
| Total | 124 | 22 | 146 | Total | 124 | 22 | 146 |
| (b) | |||||||
| 0 | 19 (90%) | 2 (10%) | 21 | 0 | 2 (100%) | 0 (0%) | 2 |
| 1+ | 1 (25%) | 3 (75%) | 4 | 1+ | 16 (94%) | 1 (6%) | 17 |
| 2+ | 0 (0%) | 6 (100%) | 6 | 2+ | 2 (33%) | 4 (66%) | 6 |
| 3+ | 0 (0%) | 11 (100%) | 11 | 3+ | 0 (0%) | 17 (100%) | 17 |
| Total | 20 | 22 | 42 | Total | 20 | 22 | 42 |