Table I.
Model rates | Parameters to estimate |
Description |
---|---|---|
μ1(s) = μ01[1 + f(s; y1, y2)] | μ0, y1, y2 | First mutation rate (initiation) |
μ2(s) = μ02[1 + f(s; m1, m2)] | m1, m2 | Rate of malignant transformation |
ε(s) = α – β = ε0[1 + f(s; ε1, ε2)] | ε0, ε1, ε2 | Rate of net clonal expansion of I-cells |
The model rates and their parameterizations are given together with the free parameters and a description of the model rates. The restriction μ01 = μ02 = μ0 is used together with N = 107.