Table 4.
The Frequency of High Gleason Grade Disease Amongst Carriers and Non-Carriers (Defined by Best-Fit Genetic Model) of the Risk Alleles
| SNP | Chrom. Location |
Percent of Men with Clinical Gleason ≥7 (n=38) |
Percent of Men with Pathologic Gleason ≥7 (n=66) | ||||
|---|---|---|---|---|---|---|---|
| Carriers | NC | p-value | Carriers | NC | p-value | ||
| rs721048 | 2p15 | 25.0 (2/8) | 18.5 (2/8) | 0.65 | 25.0 (2/8) | 32.8 (64/195) | 0.99 |
| rs10934853 | 3q21 | 15.3 (16/105) | 22.5 (16/105) | 0.21 | 31.4 (33/105) | 33.7 (33/98) | 0.77 |
| rs2736098 | 5p15 | 26.3 (5/19) | 17.9 (33/184) | 0.36 | 26.3 (5/19) | 33.2 (61/184) | 0.62 |
| rs401681 | 5p15 | 18.5 (30/162) | 19.5 (8/41) | 0.83 | 33.3 (54/162) | 29.3 (12/41) | 0.71 |
| rs16901979 | 8q24 | 30.4 (7/23) | 17.2 (31/180) | 0.15 | 47.8 (11/23) | 30.6 (55/180) | 0.10 |
| rs16902094 | 8q24 | 21.7 (13/60) | 17.5 (25/143) | 0.55 | 31.7 (19/60) | 32.9 (47/143) | 0.99 |
| rs445114 | 8q24 | 19.7 (35/178) | 12.0 (3/25) | 0.58 | 33.2 (59/178) | 28.0 (7/25) | 0.66 |
| rs6983267 | 8q24 | 17.8 (31/174) | 24.1 (7/29) | 0.44 | 32.8 (57/174) | 31.0 (9/29) | 0.99 |
| rs1447295 | 8q24 | 18.2 (10/55) | 18.9 (28/148) | 0.99 | 36.4 (20/55) | 31.1 (46/148) | 0.50 |
| rs10993994 | 10q11 | 11.3 (6/53) | 21.3 (32/150) | 0.15 | 34.0 (18/53) | 32.0 (48/150) | 0.86 |
| rs11228565 | 11q13 | 18.2 (16/87) | 19.0 (22/116) | 0.99 | 37.9 (33/87) | 28.5 (33/116) | 0.17 |
| rs10896450 | 11q13 | 18.5 (30/162) | 19.5 (8/41) | 0.83 | 31.5 (51/162) | 36.6 (15/41) | 0.58 |
| rs11649743 | 17q12 | 17.9 (25/140) | 20.6 (13/63) | 0.70 | 30.7 (43/140) | 36.5 (23/63) | 0.43 |
| rs4430796 | 17q12 | 19.8 (31/157) | 15.2 (7/46) | 0.67 | 31.9 (50/157) | 34.8 (16/46) | 0.72 |
| rs1859962 | 17q24 | 16.3 (10/62) | 19.9 (28/141) | 0.70 | 25.8 (16/62) | 35.5 (50/141) | 0.20 |
| rs8102476 | 19q13 | 18.5 (32/173) | 20.0 (6/30) | 0.80 | 34.1 (59/173) | 23.3 (7/30) | 0.30 |
| rs5945572 | Xp11 | 16.3 (14/86) | 20.5 (24/117) | 0.47 | 25.6 (22/86) | 37.6 (44/117) | 0.10 |