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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Stroke. 2011 Mar 24;42(5):1351–1356. doi: 10.1161/STROKEAHA.110.596874

Table 2.

Univariate Predictors of Brain Tissue Hypoxia and Metabolic Crisis

Variable Metabolic Crisis Brain Tissue Hypoxia
OR (95%-CI) P Value OR (95%-CI) P Value
Age >47 years 0.5 (0.1–1.6) .232 0.8 (0.2–2.7) .762
Non-white 1.9 (0.6–6.8) .295 1.8 (0.5–6.3) .378
SAH day 1.1 (0.9–1.2) .506 1.1 (0.9–1.2) .437
Peri-lesional probe location 2.4 (0.7–8.8) .175 0.8 (0.2–5.1) .763
Hunt -Hess grade 5 3.9 (1.2–13) .021 0.9 (0.3–2.8) .843
Apache II subscore >10 1.0 (0.9–1.1) .946 1.1 (0.9–1.2) .293
SAH sum score ≥15 0.8 (0.2–3.9) .775 1.9 (0.6–6.0) .244
IVH present 4.2 (1.0–17) .046 2.3 (0.8–6.4) .110
ICH present 10 (2.1–46) .003 0.2 (0.1–2.6) .198
Bicaudate index >.2 4.8 (1.4–16) .011 1.6 (0.5–5.1) .415
CPP ≤ 70 mm Hg 1.6 (1.2–2.1) .001 1.4 (1.1–1.8) .005
ICP >20 mm Hg 1.0 (1.0–1.1) .001 1.0 (0.9–1.0) .319
ETCO2 <35 mm Hg 1.0 (0.7–1.4) .972 1.3 (1.1–1.6) .014
ORx > 0.2 1.0 (0.9–1.1) .590 0.9 (0.8–1.1) .097
PRx > 0.2 1.0 (0.9–1.2) .864 1.1 (1.0–1.2) .074
Serum glucose < 6.6 mmol/L 1.3 (1.0–1.6) .026 1.0 (0.9–1.1) .831

OR (95%-CI) = Odds Ratio (95% Confidence Interval); Metabolic Crisis=Lactate / Pyruvate Ratio > 40 and brain glucose concentration < 0.7 mmol/L; Brain Tissue Hypoxia PbtO2<20 mm Hg; Age cutoff at median (47 years old); SAH ≥15=SAH sum score, scaled 0=no blood, 30=all cisterns and fissures completely filled42 ; IVH=intraventricular blood present43 ; bicaudate index=presence of cerebral edema44 ; ORx= Oxygen PbtO2 Pressure Reactivity Index; PRx=Pressure Reactivity Index.