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. 1993 Feb 11;21(3):455–461. doi: 10.1093/nar/21.3.455

Functional analysis of the human neurofilament light chain gene promoter.

K Yazdanbakhsh 1, P Fraser 1, D Kioussis 1, M Vidal 1, F Grosveld 1, M Lindenbaum 1
PMCID: PMC309139  PMID: 8441658

Abstract

We have carried out a structural and functional analysis on the human NF-L (H-NF-L) gene. It contains a methylation-free island, spanning the 5' flanking sequences and the first exon and a number of neuronal-specific DNase I hypersensitive sites have been identified in the upstream region as well as within the body of the gene. Analysis in cell lines and transgenic mice using a combination of these sites has revealed the presence of a conserved element(s) between -300bp and -190bp which is required for neuronal-specific expression.

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