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. 2011 May 4;134(5):1293–1314. doi: 10.1093/brain/awr074

Figure 8.

Figure 8

Decreased numbers of Tregs in blood are inversely correlated with a rapid rate of progression in patients with ALS. (A) Using the Appel ALS (AALS) scoring system, there were 27% fewer CD4+ T lymphocytes in rapidly progressing patients with ALS (a disease progression rate of ≥1.5 Appel ALS points/month) compared with slowly progressing patients with ALS (a disease progression rate of <1.5 Appel ALS points/month; P = 0.02). Rapidly progressing patients had fewer CD4+ T lymphocytes than volunteer subjects (P = 0.009). (B) There were 31% fewer CD4+CD25+ Tregs in rapidly progressing patients (≥1.5 Appel ALS points/month) compared with slowly progressing patients (<1.5 Appel ALS points/month) (P = 0.02); volunteer control subjects had 47% more CD4+CD25+ Tregs than rapidly progressing patients (P = 0.003). (C) There was a linear inverse correlation between the number of CD4+CD25+ Tregs in the blood of patients with ALS and rate of disease progression (P = 0.03).