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. Author manuscript; available in PMC: 2012 May 17.
Published in final edited form as: Biochemistry. 2011 Apr 19;50(19):3903–3912. doi: 10.1021/bi200083d

Table 1.

Thermodynamic properties of DNA/RNA hybrids containing a central Rp or Sp BH3 DNA backbone modification and an unmodified control in 10 mM sodium phosphate, 50 mM NaCl, pH 6.4. TM values were calculated for a 30 μM duplex. ΔG are given for 298 K.

TM (K) ΔH (kJ/mol) ΔS (kJ/mol K) ΔG (kJ/mol)
Rp hybrid 313.8 (0.2) 265 (6) 0.747 (0.018) 42.6
Sp hybrid 313.8 (0.2) 263(15) 0.739 (0.043) 42.4
Controla 312.9 (0.1) 253 (7) 0.706 (0.022) 42.2
a

Control sample from previously published work at similar conditions (22).