TABLE 1. Study Treatment Regimen for Infantile Spasms.

A. Two-week treatment schedule:

ACTH: 75 U/m2 twice a day, intramuscularly

Prednisone: 1 mg/kg twice a day, orally

Monitoring: Electrolytes, glucose at onset and end.

Glycosuria: all specimens.

Blood-pressure: twice a week.

B. Tapering schedules:

ACTH: For 3 days 30 U/M2 in the morning.

For 3 days 15 U/m2 in the morning.

For 3 days 10 U/m2 in the morning.

For 6 days 10 U/m2 every other morning.

Prednisone: For 3 days the morning dose (1 mg/kg) only.

For 6 days half the morning dose (0.5 mg/kg) only.

For 6 days 0.5 mg/kg every other morning.