To the Editor: We read with great interest the article by Chishti et al,1 and would like to congratulate the authors for developing these timely guidelines. However, the authors mentioned that febrile urinary tract infection associated renal scarring is highest in the first year of life. For infants less than one year of age, it would be more appropriate to use the term renal parenchymal defect instead of scarring, as recommended by the NICE guidelines.2 Parenchymal defects discovered in infancy are usually the result of renal dysplasia rather than acquired scars. Renal dysplasia occurs when the developing kidney is subjected to an in utero insult, including vesicoureteral reflux, at a critical period of nephrogenesis.3 Along the same lines, in the dysplastic kidney, recurrent febrile urinary tract infections add insult to injury, thus speeding up kidney function deterioration.4
Authors of original article declined to respond.
REFERENCES
- 1.Chishti AS, Maul EC, Nazaio RJ, Bennett JS, Kiessling SG. A guideline for the inpatient care of children with pyelonephritis. Ann Saudi Med. 2010;30(5):341–9. doi: 10.4103/0256-4947.68549. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Mori R, Lakhanpaul M, Verrier-Jones K. Diagnosis and management of urinary tract infection in children: summary of NICE guidance. BMJ. 2007;335:395–7. doi: 10.1136/bmj.39286.700891.AD. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 3.Shibala S, Nagata M. Pathogenesis of human renal dysplasia : an alternative scenario to the major theories. Pediatr Int. 2003;45:605–09. doi: 10.1046/j.1442-200x.2003.01778.x. [DOI] [PubMed] [Google Scholar]
- 4.Celedon CG, Bitsori M, Tullus K. Progression of chronic renal failure in children with dysplastic kidneys. Pediatr Nephrol. 2007;22(7):1014–1020. doi: 10.1007/s00467-007-0459-5. [DOI] [PubMed] [Google Scholar]