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. 1994 Aug 11;22(15):3026–3032. doi: 10.1093/nar/22.15.3026

A new ATP-independent DNA endonuclease from Schizosaccharomyces pombe that recognizes cyclobutane pyrimidine dimers and 6-4 photoproducts.

K K Bowman 1, K Sidik 1, C A Smith 1, J S Taylor 1, P W Doetsch 1, G A Freyer 1
PMCID: PMC310271  PMID: 8065916

Abstract

We have discovered a new DNA endonuclease in the fission yeast Schizosaccharomyces pombe which recognizes cyclobutane pyrimidine dimers and (6-4) pyrimidine-pyrimidone photoproducts. S. pombe DNA endonuclease (SPDE) catalyzes a single ATP-independent incision immediately 5' to the UV photoproduct and generates termini containing 3' hydroxyl and 5' phosphoryl groups. Based on these properties, we propose that SPDE may function in a DNA repair capacity, representing the initial recognition/cleavage step of a DNA excision repair pathway.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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