Table 4.
Kinetic pKa Values from pH-Rate Profiles of Zn and Fe Substituted CDA and Mutant.
| pKa | pKb | |||
|---|---|---|---|---|
| enzyme | metal | kcat vs pH | kcat/Km vs pH | kcat/Km vs pH |
| wild type | Zn2+ | 7.3 ± 0.1 | 5.5 ± 0.2 | 7.9 ± 0.4 |
| wild type | Fe2+ | 6.0 ± 0.1 | - | 8.2 ± 0.2 |
| H246Q | Zn2+ | - | - | - |
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