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. 1986 Jul 11;14(13):5399–5407. doi: 10.1093/nar/14.13.5399

Synthesis of DNA via deoxynucleoside H-phosphonate intermediates.

B C Froehler, P G Ng, M D Matteucci
PMCID: PMC311548  PMID: 3737406

Abstract

Deoxynucleoside H-phosphonates are used in the chemical synthesis of deoxyoligonucleotides up to 107 bases in length. The biological activity of the synthetic DNA is assessed by cloning into M13 and sequencing. An improved synthesis of protected deoxynucleoside H-phosphonates is also described.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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