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. 1986 Aug 11;14(15):6313–6326. doi: 10.1093/nar/14.15.6313

Analysis of the RNA structural elements involved in the binding of the transcription factor III A from Xenopus laevis.

T Pieler, U Guddat, S L Oei, V A Erdmann
PMCID: PMC311638  PMID: 3748810

Abstract

Xenopus laevis 5S rRNA isolated from 7S particles or transcribed in vitro is found to adopt two alternative conformations. These two conformers contain different structural elements within the major TF III A binding domain, which, when isolated as RNA fragments, still interact with the transcription factor. Chemical modification of easily accessible adenines in their N-1 position does not have any measurable effect on the binding of 5S rRNA to TF III A. These observations are in support of the idea that only a small amount of conserved sequence information is required for the binding of the transcription factor, whereas specific secondary structure features seem to be essential.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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