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. 1986 Aug 26;14(16):6345–6355. doi: 10.1093/nar/14.16.6345

Diversity in G + C content at the third position of codons in vertebrate genes and its cause.

S Aota, T Ikemura
PMCID: PMC311650  PMID: 3748815

Abstract

Correlation was positive between the G + C content at the codon third position in genes of vertebrates and the G + C content of the genome portion surrounding each gene. Exons of genes with a high G + C% at the codon 3rd position are surrounded by G + C-rich introns and G + C-rich flanking sequences, and those with a low G + C% at the position by A + T-rich introns and flanking sequences. Analysis of G + C content distribution along DNA sequences using a DNA Sequence Data Bank supported the view that the vertebrate genome is a mosaic of regions with clear differences in their G + C content. The biological significance of the variation in G + C content throughout the vertebrate genome is discussed in connection with chromosomal banding.

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Selected References

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