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. 1986 Sep 11;14(17):7017–7029. doi: 10.1093/nar/14.17.7017

Gamma delta beta-thalassaemias 1 and 2 are the result of a 100 kbp deletion in the human beta-globin cluster.

R Taramelli, D Kioussis, E Vanin, K Bartram, J Groffen, J Hurst, F G Grosveld
PMCID: PMC311714  PMID: 3763397

Abstract

The DNA spanning two large deletions in the human beta-globin gene cluster (gamma beta-thalassaemia 1 and 2) has been cloned by cosmid cloning and chromosomal walking. The entire region was mapped and analyzed for the presence of repetitive sequences. The results show that the affected loci have lost almost 100 kb of DNA in a deletion event not involving homologous or repetitive sequences.

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Selected References

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