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. 1986 Sep 25;14(18):7253–7263. doi: 10.1093/nar/14.18.7253

Alteration of cellular gene expression in adenovirus transformed cells by post-transcriptional mechanisms.

H T Kao, J R Nevins
PMCID: PMC311750  PMID: 3763404

Abstract

We have isolated cDNA clones complementary to human mRNAs that are expressed at elevated levels in 293 cells, adenovirus-transformed human embryonic kidney cells, as compared to a normal counterpart of this cell line. Approximately 200 clones out of 100,000 that were screened were positive; 40 of these were isolated, of which 31 were determined to be unique and were further characterized. Each clone detected a mRNA that was 5 to 50 times more abundant in 293 cells than in the non-transformed HEK cell line. For several of these transcripts, the elevated expression appeared to be a function of transformation since they were also high in other human tumor cell lines. Strikingly, we have found that post-transcriptional control is largely responsible for the regulation of the abundance of these mRNAs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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