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. 1986 Oct 24;14(20):7883–7896. doi: 10.1093/nar/14.20.7883

Isolation and sequence of a human gene encoding a potent inhibitor of leukocyte proteases.

G Stetler, M T Brewer, R C Thompson
PMCID: PMC311822  PMID: 3640338

Abstract

We report the isolation of the human gene encoding an inhibitor of neutrophil elastase and cathepsin G. We have sequenced the gene and a cDNA clone isolated from human parotid tissue. The protein encoded by this gene appears to contain two functional domains, one having a trypsin inhibitory site and the other an elastase inhibitory site. The two-domain structure of the protein is reflected in the organization of the gene, with each domain represented by a separate exon. We have also noted that the intervening sequence separating the trypsin-inhibitor-exon and the elastase-inhibitor-exon is flanked by eleven base-pair direct repeats, suggesting that this intron may have been generated by a transposition-type event.

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Selected References

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