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. 1986 Oct 24;14(20):7897–7914. doi: 10.1093/nar/14.20.7897

Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene.

B D Clark, K L Collins, M S Gandy, A C Webb, P E Auron
PMCID: PMC311823  PMID: 3490654

Abstract

We have isolated the human prointerleukin 1 (proIL-1) beta gene from leukocyte and fetal liver libraries. The nucleotide sequence and its gene organization reveals that the proIL-1 beta gene is composed of seven exons with a primary transcription product length of 7,008 nucleotides. The exon sequence agrees well with that of the human proIL-1 beta cDNA. Features of interest within the transcriptional unit include positioned TATA, CAT, and poly-adenylation signals for gene regulation, as well as the signatures of gene duplication via retrotransposition in the form of flanking direct repeats and a genomic poly A tail. The genomic organization of the proIL-1 beta gene with respect to the number and position of exon boundaries is strikingly similar to that of the recently reported human proIL-1 alpha gene. Therefore, we hypothesize that the proIL-1 beta may have arisen by a reverse transcriptase mediated duplication of the related alpha gene.

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Selected References

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