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. Author manuscript; available in PMC: 2011 Jun 20.
Published in final edited form as: Thorax. 2010 Apr;65(4):346–353. doi: 10.1136/thx.2008.101139

Figure 7. Schematic of heat stress inhibition of STAT1 and iNOS signaling pathways.

Figure 7

Heat stress or treatment of macrophages with 17-AAG results in the disruption of the STAT1-Hsp90 complex preventing STAT1 phosphorylation and translocation to the nucleus. Post-heat stress when the STAT1 signaling pathway is responsive to IFN-γ stimulation, nitric oxide production from iNOS is inhibited due to the inducible form of Hsp70.