Skip to main content
. Author manuscript; available in PMC: 2012 Jul 14.
Published in final edited form as: Neuroscience. 2011 Apr 30;186:179–187. doi: 10.1016/j.neuroscience.2011.04.049

Figure 2. Gene expression of mechanosensitive K2P channels in DRG neurons innervating the mouse bladder or distal colon.

Figure 2

(A) Representative photographs of RT-PCR products of GAPDH, TREK-1, TREK-2 and TRAAK from 3 colon DRG neurons (lanes 1~3, (-) indicates no template control for GAPDH screening). The expected amplicon sizes were 242 bp (GAPDH), 229 bp (TREK-1), 254 bp (TREK-2) and 109 bp (TRAAK). (B) The gene transcripts of all three mechanosensitive K2P channels, TREK-1, TREK-2 and TRAAK, were detected in bladder- and colon-DRG neurons in both TL and LS ganglia. TREK-1 mRNA was most prevalent. The proportion of neurons expressing TREK-1 mRNA was less in TL than in LS ganglia in both organs († P<0.05 and †††† P<0.0001 vs. LS) and in colon- than in bladder-DRG neurons (*** P<0.001 by FET).