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. Author manuscript; available in PMC: 2011 Jun 20.
Published in final edited form as: Neuroscience. 2005;132(4):1017–1026. doi: 10.1016/j.neuroscience.2005.01.041

Fig. 5.

Fig. 5

Dose-response curves showing the effects of graded doses of MK-801 (0.6–60 μg) by i.t. injections on the bladder contraction amplitude and EUS EMG activity during continuous filling (0.21 ml/min) CMGs in urethane-anesthetized rats (n=5; a) and the effects of MK-801 (0.6, 6 and 60 μg i.t.) on micturition reflex during single slow infusion (0.04 ml/min) CMGs in urethane-anesthetized rats (n=6; b–g). Abscissa, the doses of MK-801 plotted on a log scale. Ordinate, bladder contraction amplitude or EUS EMG activity as a % of control (a), voided volume (ml; b), residual volume (ml; c), volume threshold for inducing micturition (ml; d), voiding efficiency (%; e), bladder contraction amplitude (cm H2O; f) and pressure threshold for inducing micturition (cm H2O; g) Mean ± S.E.M. is plotted for each point. The. raw values at individual doses are compared with those of controls using Dunnett’s multiple comparisons test (* P<0.05, ** P<0.01) following repeated measures ANOVA. C, control.