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. 1986 Dec 9;14(23):9509–9519. doi: 10.1093/nar/14.23.9509

Replication timing: histone genes replicate during early S phase in cleavage-stage embryos of sea urchin.

N Watanabe, K Akasaka, T Shiroya, M Obinata, H Shimada
PMCID: PMC311973  PMID: 3797246

Abstract

Newly synthesized DNA was separated from the bulk of the DNA by pulse-labeling with BUdR and centrifugation in an alkaline CsCl buoyant density gradient. The content of histone gene in the newly synthesized DNA was determined by DNA dot hybridization. The gene contents in DNA replicated during the early half of S phase and during the whole S phase were compared. Results showed that histone genes were replicated during the first half of the S phase in embryos in the early cleavage stage.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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