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. 1992 Apr 11;20(7):1599–1606. doi: 10.1093/nar/20.7.1599

The murine Hox-2.4 promoter contains a functional octamer motif.

F Zwartkruis 1, T Hoeijmakers 1, J Deschamps 1, F Meijlink 1
PMCID: PMC312244  PMID: 1349742

Abstract

Like other HOX genes the murine Hox-2.4 gene is thought to be involved in regional specification along the antero-posterior axis. In addition it has been reported to have oncogenic potential. We studied expression Hox-2.4 in murine EC cells and determined the transcription start site. Studies of DNA-protein interactions in the promoter region showed that the Hox-2.4 promoter contains a CCAAT box and a perfect octamer motif, which is capable of binding Oct-factors. Cotransfection of Oct expression vectors influences the transcriptional activity of the promoter, suggesting that the Oct-gene family may be involved in regulating HOX genes.

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Selected References

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