Table 2.
List of Genes Whose Acetic Acid-Induced Transcriptional Activation Registered in S. cerevisiae BY4741 (Above 1.5-Fold) Is Reduced, But Not Eliminated, in the ΔHAA1 Background
| |
|
(mRNA wt )ac |
(mRNA Δhaa1 )ac |
(mRNA wt )ac |
|
Induced by |
|||
|---|---|---|---|---|---|---|---|---|---|
| Gene or ORF | Biological function | (mRNA wt)c | (mRNA Δhaa1)c | (mRNA Δhaa1)ac | Acetic acid susceptibility | Actld. | Prop. | Sorb. | Lact. |
| YPR157w | Unknown function | 32.6 | 2.2 | 19.2 | − | ||||
| STP4 | Putative transcription factor | 12.6 | 2.2 | 12.7 | − | ||||
| YDR222w | Unknown function | 10.9 | 1.6 | 9.5 | − | ||||
| YPL014w | Unknown function | 10.3 | 1.8 | 7.3 | − | ||||
| PHM8 | Unknown function; expression regulated by phosphate availability | 15.6 | 2.8 | 6.3 | − | ||||
| YER130c | Unknown function | 10.9 | 2.4 | 4.7 | − | ||||
| TPO3 | Plasma membrane polyamine transporter of the major facilitator superfamily | 4.8 | 1.8 | 3.7 | ++ | ||||
| HSP30 | Putative negative regulator of plasma membrane H+-ATPase activity; expression induced under stress | 86.9 | 54.1 | 3.5 | − | ||||
| YPC1 | Alkaline ceramidase involved in sphingolipid and ceramide metabolism | 9.3 | 2.6 | 3.4 | + | ||||
| SSE2 | Heat-shock protein involved in protein folding; expression induced under stress | 6.8 | 3.1 | 2.9 | + | ||||
| SCM4 | Putative regulator of Cdc4p activity required for G1/S phase transition | 3.8 | 2.1 | 2.7 | − | ||||
| HSP26 | Heat-shock protein involved in protein folding; expression induced under stress | 2.7 | 1.9 | 2.5 | − | ||||
| YGR250c | Unknown function | 6.5 | 3.5 | 2.3 | − | ||||
| SKS1 | Putative serine/threonine protein kinase involved in adaptation to glucose starvation | 4.4 | 2.3 | 2.3 | − | ||||
| MTH1 | Negative regulator of the glucose-sensing signal transduction pathway | 3.1 | 1.7 | 2.1 | − | ||||
| FMP48 | Putative mithocondrial protein; unknown function | 28.2 | 16.1 | 2 | ++ | ||||
| RGS2 | Negative regulator of glucose-induced cAMP signaling pathway | 5.2 | 2.9 | 2 | − | ||||
| ECM13 | Unknown function | 6.8 | 3.0 | 2 | − | ||||
| HRK1 | Protein kinase implicated in activation of the plasma membrane H+-ATPase in response to glucose metabolism | 2.1 | 1.8 | 1.9 | +++ | ||||
| CUR1 | Unknown function | 2.3 | 1.5 | 1.7 | − | ||||
| PDR16 | Phosphatidylinositol transfer protein | 2.3 | 1.6 | 1.6 | − | ||||
The genes indicated in this table are only those whose transcript level in Δhaa1 acetic acid-stressed cells is 25% below the values attained in the parental strain, as for Table 1 legend.