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Induction of P450 3A4 activity in COL and OS187 cell lines by etoposide, doxorubicin, and ifosfamide represented by control; etoposide; etoposide + ketoconazole doxorubicin; and ifosfamide. CYP3A catalytic activity was measured using 7-benzyl-trifluoromethyl coumarin (BFC) as a probe substrate as described in Materials and Methods.
