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. 1989 Feb;57(2):630–632. doi: 10.1128/iai.57.2.630-632.1989

Antibodies raised against synthetic peptides from the Arg-Gly-Asp-containing region of the Leishmania surface protein gp63 cross-react with human C3 and interfere with gp63-mediated binding to macrophages.

D G Russell 1, P Talamas-Rohana 1, J Zelechowski 1
PMCID: PMC313143  PMID: 2912899

Abstract

The Leishmania surface glycoprotein gp63 binds to complement receptor type 3 on the macrophage surface. Antibody raised against a synthetic peptide containing the Arg-Gly-Asp region of the amino acid sequence of gp63 recognizes both gp63 and the alpha-chain of human C3. Monovalent Fab fragments from this antibody block gp63-mediated binding to macrophages.

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Selected References

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