Skip to main content
Infection and Immunity logoLink to Infection and Immunity
. 1989 Feb;57(2):653–655. doi: 10.1128/iai.57.2.653-655.1989

Vaccination of mice against Mycobacterium leprae infection.

N B Singh 1, A C Lowe 1, R J Rees 1, M J Colston 1
PMCID: PMC313150  PMID: 2643581

Abstract

Intradermal immunization with killed Mycobacterium leprae renders mice immune to infection with viable M. leprae. This protection is long lasting and systemic in that immunization in the left flank results in protection in both the left and right footpads. Immunization with Mycobacterium vaccae was ineffective in protecting mice against M. leprae infection, while Mycobacterium bovis BCG provided partial protection. Mycobacterium habana TMC 5135 (now known as Mycobacterium simiae) was found to be as effective as M. leprae in protecting mice against footpad infection.

Full text

PDF
653

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Graham L., Jr, Navalkar R. G. Evaluation of Mycobacterium leprae immunogenicity via adoptive transfer studies. Infect Immun. 1984 Jan;43(1):79–83. doi: 10.1128/iai.43.1.79-83.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Gupta H. P., Singh N. B., Mathur I. S., Gupta S. K. Mycobacterium habana, a new immunogenic strain in experimental tuberculosis of mice. Indian J Exp Biol. 1979 Nov;17(11):1190–1193. [PubMed] [Google Scholar]
  3. Kingston A. E., Stagg A. J., Colston M. J. Investigation of antigen cross-reactivity of Mycobacterium leprae-reactive murine T-cell lines and clones. Immunology. 1986 Jun;58(2):217–223. [PMC free article] [PubMed] [Google Scholar]
  4. Krahenbuhl J. L., Humphres R. C. Effects of treatment with muramyl dipeptide on resistance to Mycobacterium leprae and Mycobacterium marinum infection in mice. Immunopharmacology. 1983 Apr;5(4):329–339. doi: 10.1016/0162-3109(83)90048-6. [DOI] [PubMed] [Google Scholar]
  5. Lowe C., Brett S. J., Rees R. J. Adoptive cell transfer of resistance to Mycobacterium leprae infections in mice. Clin Exp Immunol. 1985 Aug;61(2):336–342. [PMC free article] [PubMed] [Google Scholar]
  6. Meissner G., Schröder K. H. Relationship between Mycobacterium simiae and Mycobacterium habana. Am Rev Respir Dis. 1975 Feb;111(2):196–200. doi: 10.1164/arrd.1975.111.2.196. [DOI] [PubMed] [Google Scholar]
  7. REES R. J. LIMITED MULTIPLICATION OF ACID-FAST BACILLI IN THE FOOT-PADS OF MICE INOCULATED WITH MYCOBACTERIUM LEPRAE. Br J Exp Pathol. 1964 Apr;45:207–218. [PMC free article] [PubMed] [Google Scholar]
  8. Shepard C. C., Van Landingham R., Walker L. L. Immunity to Mycobacterium leprae infections in mice stimulated by M. leprae, BCG, and graft-versus-host reactions. Infect Immun. 1976 Oct;14(4):919–928. doi: 10.1128/iai.14.4.919-928.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Shepard C. C., van Landingham R. M., Walker L. L., Ye S. Z. Comparison of the immunogenicity of vaccines prepared from viable Mycobacterium bovis BCG, heat-killed Mycobacterium leprae, and a mixture of the two for normal and M. leprae-tolerant mice. Infect Immun. 1983 Jun;40(3):1096–1103. doi: 10.1128/iai.40.3.1096-1103.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Shepard C. C., van Landingham R., Walker L. L. Searches among mycobacterial cultures for antileprosy vaccines. Infect Immun. 1980 Sep;29(3):1034–1039. doi: 10.1128/iai.29.3.1034-1039.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Singh N. B., Srivastava, Gupta H. P., Sreevatsa, Desikan K. V. Immunological potential of a cultivable mycobacterial strain M. habana against leprosy bacillus in mouse foot pad. Indian J Lepr. 1985 Apr-Jun;57(2):278–281. [PubMed] [Google Scholar]
  12. Swinburne S., Brown I. N., Brown C. A. Mycobacterium vaccae and immune responses: implications for leprosy control. Lepr Rev. 1985 Sep;56(3):209–220. [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES