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. 1989 Mar;57(3):918–925. doi: 10.1128/iai.57.3.918-925.1989

Ureaplasma urealyticum pneumonia: experimental production and demonstration of age-related susceptibility.

P T Rudd 1, G H Cassell 1, K B Waites 1, J K Davis 1, L B Duffy 1
PMCID: PMC313199  PMID: 2917792

Abstract

Two different strains of Ureaplasma urealyticum isolated in pure culture from the lungs of newborn human infants were shown to produce an acute, self-limiting, interstitial pneumonia in newborn C3H/HeN and C57BL/6 mice that were free of other respiratory pathogens. Lesion severity peaked 3 to 6 days following intranasal inoculation of ureaplasmas and was resolved by 12 days. Rhinitis and otitis also occurred but did so less frequently than pneumonia. Organisms were localized within the alveoli in areas of inflammation. In comparison with newborn mice, 14-day-old mice were less susceptible to either colonization or disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cassell G. H., Crouse D. T., Waites K. B., Rudd P. T., Davis J. K. Does Ureaplasma urealyticum cause respiratory disease in newborns? Pediatr Infect Dis J. 1988 Aug;7(8):535–541. [PubMed] [Google Scholar]
  2. Cassell G. H., Davis R. O., Waites K. B., Brown M. B., Marriott P. A., Stagno S., Davis J. K. Isolation of Mycoplasma hominis and Ureaplasma urealyticum from amniotic fluid at 16-20 weeks of gestation: potential effect on outcome of pregnancy. Sex Transm Dis. 1983 Oct-Dec;10(4 Suppl):294–302. [PubMed] [Google Scholar]
  3. Cassell G. H., Lindsey J. R., Davis J. K., Davidson M. K., Brown M. B., Mayo J. G. Detection of natural Mycoplasma pulmonis infection in rats and mice by an enzyme linked immunosorbent assay (ELISA). Lab Anim Sci. 1981 Dec;31(6):676–682. [PubMed] [Google Scholar]
  4. Cassell G. H. Ureaplasmas of human: with emphasis upon maternal and neonatal infections. Future considerations: maternal and neonatal aspects. Pediatr Infect Dis. 1986 Nov-Dec;5(6 Suppl):S341–S344. [PubMed] [Google Scholar]
  5. Cassell G. H., Waites K. B., Crouse D. T., Rudd P. T., Canupp K. C., Stagno S., Cutter G. R. Association of Ureaplasma urealyticum infection of the lower respiratory tract with chronic lung disease and death in very-low-birth-weight infants. Lancet. 1988 Jul 30;2(8605):240–245. doi: 10.1016/s0140-6736(88)92536-6. [DOI] [PubMed] [Google Scholar]
  6. Davis J. K., Parker R. F., White H., Dziedzic D., Taylor G., Davidson M. K., Cox N. R., Cassell G. H. Strain differences in susceptibility to murine respiratory mycoplasmosis in C57BL/6 and C3H/HeN mice. Infect Immun. 1985 Dec;50(3):647–654. doi: 10.1128/iai.50.3.647-654.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. De Silva N. S., Quinn P. A. Endogenous activity of phospholipases A and C in Ureaplasma urealyticum. J Clin Microbiol. 1986 Feb;23(2):354–359. doi: 10.1128/jcm.23.2.354-359.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Dische M. R., Quinn P. A., Czegledy-Nagy E., Sturgess J. M. Genital mycoplasma infection. Intrauterine infection: pathologic study of the fetus and placenta. Am J Clin Pathol. 1979 Aug;72(2):167–174. doi: 10.1093/ajcp/72.2.167. [DOI] [PubMed] [Google Scholar]
  9. Fodor M. Difference in the virulence of Ureaplasma urealyticum isolates. Acta Microbiol Acad Sci Hung. 1980;27(2):161–169. [PubMed] [Google Scholar]
  10. Goldstein E. An assessment of animal models for testing the effect of photochemical oxidants on pulmonary susceptibility to bacterial infection. J Toxicol Environ Health. 1984;13(2-3):415–421. [PubMed] [Google Scholar]
  11. Horowitz S. A., Duffy L., Garrett B., Stephens J., Davis J. K., Cassell G. H. Can group- and serovar-specific proteins be detected in Ureaplasma urealyticum? Pediatr Infect Dis. 1986 Nov-Dec;5(6 Suppl):S325–S331. doi: 10.1097/00006454-198611010-00029. [DOI] [PubMed] [Google Scholar]
  12. Kim K. S., Dunn K., McGeary S. A., Stiehm E. R. Efficacy of orally administered immune serum globulin against type III group B streptococcal colonization and systemic disease in an infant rat model. Pediatr Res. 1984 Dec;18(12):1329–1331. doi: 10.1203/00006450-198412000-00022. [DOI] [PubMed] [Google Scholar]
  13. Lamb D. Rat lung pathology and quality of laboratory animals: the user's view. Lab Anim. 1975 Jan;9(1):1–8. doi: 10.1258/002367775780994781. [DOI] [PubMed] [Google Scholar]
  14. Martin T. R., Rubens C. E., Wilson C. B. Lung antibacterial defense mechanisms in infant and adult rats: implications for the pathogenesis of group B streptococcal infections in the neonatal lung. J Infect Dis. 1988 Jan;157(1):91–100. doi: 10.1093/infdis/157.1.91. [DOI] [PubMed] [Google Scholar]
  15. O'Brodovich H. M., Mellins R. B. Bronchopulmonary dysplasia. Unresolved neonatal acute lung injury. Am Rev Respir Dis. 1985 Sep;132(3):694–709. doi: 10.1164/arrd.1985.132.3.694. [DOI] [PubMed] [Google Scholar]
  16. Parker R. F., Davis J. K., Blalock D. K., Thorp R. B., Simecka J. W., Cassell G. H. Pulmonary clearance of Mycoplasma pulmonis in C57BL/6N and C3H/HeN mice. Infect Immun. 1987 Nov;55(11):2631–2635. doi: 10.1128/iai.55.11.2631-2635.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Quinn P. A. Evidence of an immune response to Ureaplasma urealyticum in perinatal morbidity and mortality. Pediatr Infect Dis. 1986 Nov-Dec;5(6 Suppl):S282–S287. doi: 10.1097/00006454-198611010-00018. [DOI] [PubMed] [Google Scholar]
  18. Quinn P. A., Gillan J. E., Markestad T., St John M. A., Daneman A., Lie K. I., Li H. C., Czegledy-Nagy E., Klein A. Intrauterine infection with Ureaplasma urealyticum as a cause of fatal neonatal pneumonia. Pediatr Infect Dis. 1985 Sep-Oct;4(5):538–543. doi: 10.1097/00006454-198509000-00020. [DOI] [PubMed] [Google Scholar]
  19. Quinn P. A., Rubin S., Nocilla D. M., Read S. E., Chipman M. Serological evidence of Ureaplasma urealyticum infection in neonatal respiratory disease. Yale J Biol Med. 1983 Sep-Dec;56(5-6):565–572. [PMC free article] [PubMed] [Google Scholar]
  20. Razin S., Yogev D. Genetic relatedness among Ureaplasma urealyticum serotypes (serovars). Pediatr Infect Dis. 1986 Nov-Dec;5(6 Suppl):S300–S304. doi: 10.1097/00006454-198611010-00022. [DOI] [PubMed] [Google Scholar]
  21. Rudd P. T., Carrington D. A prospective study of chlamydial, mycoplasmal, and viral infections in a neonatal intensive care unit. Arch Dis Child. 1984 Feb;59(2):120–125. doi: 10.1136/adc.59.2.120. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Rudd P. T., Waites K. B., Duffy L. B., Stagno S., Cassell G. H. Ureaplasma urealyticum and its possible role in pneumonia during the neonatal period and infancy. Pediatr Infect Dis. 1986 Nov-Dec;5(6 Suppl):S288–S291. doi: 10.1097/00006454-198611010-00019. [DOI] [PubMed] [Google Scholar]
  23. Sherman M., Goldstein E., Lippert W., Wennberg R. Group B streptococcal lung infection in neonatal rabbits. Pediatr Res. 1982 Mar;16(3):209–212. doi: 10.1203/00006450-198203000-00009. [DOI] [PubMed] [Google Scholar]
  24. Taylor-Robinson D., Furr P. M., Liberman M. M. The occurrence of genital mycoplasmas in babies with and without respiratory distress. Acta Paediatr Scand. 1984 May;73(3):383–386. doi: 10.1111/j.1651-2227.1994.tb17752.x. [DOI] [PubMed] [Google Scholar]

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