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. 1989 Apr;57(4):1324–1326. doi: 10.1128/iai.57.4.1324-1326.1989

Interaction of Lyme disease spirochetes with cultured eucaryotic cells.

D D Thomas 1, L E Comstock 1
PMCID: PMC313270  PMID: 2925254

Abstract

The association of the Lyme disease spirochete, Borrelia burgdorferi, with cultured human endothelial cells was investigated. Attachment was time and temperature dependent, with optimal adherence occurring after 4 h of incubation at 37 degrees C. Pretreatment of borreliae with heat, immune human serum, or monoclonal antibodies directed against outer surface protein B (OspB) reduced the attachment of organisms to host cell monolayers. These results suggest that the adherence of B. burgdorferi may be mediated, at least in part, by borrelial surface proteins.

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Selected References

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